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    1. Chromosomes and Gene Expression

    Chromatin-associated RNA sequencing (ChAR-seq) maps genome-wide RNA-to-DNA contacts

    Jason C Bell, David Jukam ... Aaron F Straight
    ChAR-seq is a massively parallelized de novo RNA mapping assay, which is capable of generating hundreds to thousands of RNA-binding maps with no a priori knowledge of target RNAs.
    1. Developmental Biology
    2. Neuroscience

    Cd59 and inflammation regulate Schwann cell development

    Ashtyn T Wiltbank, Emma R Steinson ... Sarah Kucenas
    Cd59 and developmental inflammation are key players in myelinating glial cell development, highlighting the collaboration between glia and the innate immune system to ensure normal neural development.
    1. Cancer Biology
    2. Evolutionary Biology

    Pervasive duplication of tumor suppressors in Afrotherians during the evolution of large bodies and reduced cancer risk

    Juan M Vazquez, Vincent J Lynch
    Duplication of tumor suppressor genes contributed to the evolution of large, long-lived elephants.
    1. Developmental Biology
    2. Neuroscience

    Conserved and divergent development of brainstem vestibular and auditory nuclei

    Marcela Lipovsek, Richard JT Wingate
    The development of brainstem auditory nuclei echoes the divergent evolutionary history of amniote auditory systems.
    1. Cancer Biology

    A large-scale proteomics resource of circulating extracellular vesicles for biomarker discovery in pancreatic cancer

    Bruno Bockorny, Lakshmi Muthuswamy ... Senthil K Muthuswamy
    Proteomic profiling of extracellular vesicle proteins from patients with benign and malignant pancreatic diseases offers a valuable resource for identifying biomarkers for pancreatic cancer detection.
    1. Neuroscience

    Proteome profile of peripheral myelin in healthy mice and in a neuropathy model

    Sophie B Siems, Olaf Jahn ... Hauke B Werner
    A comprehensive compendium of myelin proteins in the peripheral nervous system has been created, alongside a method to address molecular diversity of myelin sheaths in health and disease.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    cAMP signaling regulates DNA hydroxymethylation by augmenting the intracellular labile ferrous iron pool

    Vladimir Camarena, David W Sant ... Gaofeng Wang
    cAMP is identified to play a novel role in regulating DNA demethylation and gene transcription by augmenting the intracellular reactive Fe(II) pool.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Defining the interactome of the human mitochondrial ribosome identifies SMIM4 and TMEM223 as respiratory chain assembly factors

    Sven Dennerlein, Sabine Poerschke ... Peter Rehling
    Definition of the mitoribosome interactome revealed inner membrane proteins and elucidated new assembly factors of the cytochrome c reductase and cytochrome c oxidase.
    1. Cell Biology
    2. Neuroscience

    TDP-43 maximizes nerve conduction velocity by repressing a cryptic exon for paranodal junction assembly in Schwann cells

    Kae-Jiun Chang, Ira Agrawal ... Jonah R Chan
    Glial TDP-43 regulates splicing and expression of neurofascin and is required for proper assembly and maintenance of paranodal axoglial junctions.
    1. Developmental Biology

    Maternal Gdf3 is an obligatory cofactor in Nodal signaling for embryonic axis formation in zebrafish

    Brent W Bisgrove, Yi-Chu Su, H Joseph Yost
    Maternal Gdf3 and Nodal are interdependent obligatory cofactors in the fundamental patterning of the vertebrate embryonic axis of zebrafish.