179 results found
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    A Kv2 inhibitor combination reveals native neuronal conductances consistent with Kv2/KvS heteromers

    Robert G Stewart, Matthew James Marquis ... Jon T Sack
    Not revised
    Reviewed Preprint v1
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Kv2.1 mediates spatial and functional coupling of L-type calcium channels and ryanodine receptors in mammalian neurons

    Nicholas C Vierra, Michael Kirmiz ... James S Trimmer
    A potassium channel, as a nonconducting function, organizes compartmentalized neuronal calcium signaling microdomains via structural and functional coupling of plasma membrane and endoplasmic reticulum calcium channels.
    1. Developmental Biology
    2. Neuroscience

    Kv1.1 channels regulate early postnatal neurogenesis in mouse hippocampus via the TrkB signaling pathway

    Shu-Min Chou, Ke-Xin Li ... Shi-Bing Yang
    Kv1.1 potassium channels regulate postnatal neurogenesis in the hippocampus via increasing the membrane excitability that activates the TrkB signaling pathway in a cell-autonomous manner.
    1. Neuroscience

    Synaptic mechanisms underlying modulation of locomotor-related motoneuron output by premotor cholinergic interneurons

    Filipe Nascimento, Matthew James Broadhead ... Gareth Brian Miles
    The pairing of chemogenetic and electrophysiological approaches reveals mechanisms by which cholinergic synapses modulate the final motor output of the nervous system.
    1. Neuroscience

    Motor cortex analogue neurons in songbirds utilize Kv3 channels to generate ultranarrow spikes

    Benjamin M Zemel, Alexander A Nevue ... Henrique von Gersdorff
    Molecular and electrophysiological evidence shows that Kv3 subunits contribute critically to ultrashort action potential waveforms and high-frequency firing in large projection neurons in zebra finch motor nuclei controlling song production and somatic movements.
    1. Structural Biology and Molecular Biophysics

    Tarantula toxins use common surfaces for interacting with Kv and ASIC ion channels

    Kanchan Gupta, Maryam Zamanian ... Kenton J Swartz
    The tarantula toxins psalmotoxin and guangxitoxin have a similar concave surface for interacting with α-helices in voltage-gated and acid-sensing ion channels.
    1. Neuroscience

    Spatiotemporal constraints on optogenetic inactivation in cortical circuits

    Nuo Li, Susu Chen ... Karel Svoboda
    Electrophysiology measurements characterized eight optogenetic methods, including a new reporter mouse expressing soma-localized light-activated chloride channels, for inactivating small regions of mouse neocortex.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Control of Slc7a5 sensitivity by the voltage-sensing domain of Kv1 channels

    Shawn M Lamothe, Nazlee Sharmin ... Harley T Kurata
    The voltage-sensing mechanism of a subfamily of potassium channels is modulated in unconventional ways by an amino acid transporter.
    1. Neuroscience

    Ankyrin-R regulates fast-spiking interneuron excitability through perineuronal nets and Kv3.1b K+ channels

    Sharon R Stevens, Colleen M Longley ... Matthew N Rasband
    Analysis of AnkyrinR conditional knockout mice shows that AnkyrinR regulates PV+ fast-spiking interneurons by organizing and maintaining perineuronal nets and through the membrane clustering of Kv3.1b K+ channels.

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