Nicholas C Vierra, Michael Kirmiz ... James S Trimmer
A potassium channel, as a nonconducting function, organizes compartmentalized neuronal calcium signaling microdomains via structural and functional coupling of plasma membrane and endoplasmic reticulum calcium channels.
Kv1.1 potassium channels regulate postnatal neurogenesis in the hippocampus via increasing the membrane excitability that activates the TrkB signaling pathway in a cell-autonomous manner.
Filipe Nascimento, Matthew James Broadhead ... Gareth Brian Miles
The pairing of chemogenetic and electrophysiological approaches reveals mechanisms by which cholinergic synapses modulate the final motor output of the nervous system.
Benjamin M Zemel, Alexander A Nevue ... Henrique von Gersdorff
Molecular and electrophysiological evidence shows that Kv3 subunits contribute critically to ultrashort action potential waveforms and high-frequency firing in large projection neurons in zebra finch motor nuclei controlling song production and somatic movements.
The tarantula toxins psalmotoxin and guangxitoxin have a similar concave surface for interacting with α-helices in voltage-gated and acid-sensing ion channels.
Electrophysiology measurements characterized eight optogenetic methods, including a new reporter mouse expressing soma-localized light-activated chloride channels, for inactivating small regions of mouse neocortex.
Sharon R Stevens, Colleen M Longley ... Matthew N Rasband
Analysis of AnkyrinR conditional knockout mice shows that AnkyrinR regulates PV+ fast-spiking interneurons by organizing and maintaining perineuronal nets and through the membrane clustering of Kv3.1b K+ channels.