940 results found
    1. Neuroscience

    Mutant huntingtin enhances activation of dendritic Kv4 K+ channels in striatal spiny projection neurons

    Luis Carrillo-Reid et al.
    In mouse models of Huntington's disease, striatal spiny projection neurons up-regulate dendritic potassium channels, which impairs their normal function, but a zinc finger gene therapy can reverse this deficit.
    1. Neuroscience

    'Artiphysiology' reveals V4-like shape tuning in a deep network trained for image classification

    Dean A Pospisil et al.
    Single units in a deep convolutional neural network trained for image classification develop shape selectivity that is similar to that found in the primate visual cortex.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Trans-toxin ion-sensitivity of charybdotoxin-blocked potassium-channels reveals unbinding transitional states

    Hans Moldenhauer et al.
    Detection of unbinding transitional states in the charybdotoxin first-order dissociation from a Kv-channel reveals that the bound neurotoxin wobbles, suggesting diverse intermediates and dissociation pathways in this protein–protein interaction.
    1. Structural Biology and Molecular Biophysics

    Phosphatidic acid modulation of Kv channel voltage sensor function

    Richard K Hite et al.
    Phosphatidic acid influences the gating of voltage-gated K+ channels through a non-specific surface charge mechanism and through a specific interaction between a voltage sensor arginine and the primary phosphate head group on the cytoplasmic membrane leaflet.
    1. Structural Biology and Molecular Biophysics

    Tarantula toxins use common surfaces for interacting with Kv and ASIC ion channels

    Kanchan Gupta et al.
    The tarantula toxins psalmotoxin and guangxitoxin have a similar concave surface for interacting with α-helices in voltage-gated and acid-sensing ion channels.
    1. Computational and Systems Biology
    2. Neuroscience

    Attention stabilizes the shared gain of V4 populations

    Neil C Rabinowitz et al.
    Populations of neurons in the macaque visual cortex are subject to shared fluctuations in gain; these signals exhibit anatomical and functional structure, and their variability is diminished under attention.
    1. Neuroscience

    Peroxisomal dysfunctions cause lysosomal storage and axonal Kv1 channel redistribution in peripheral neuropathy

    Sandra Kleinecke et al.
    Dysfunctions of myelin peroxisomes cause a lysosomal storage-like disorder associated with alterations in glial and axonal membranes, which is the likely cause of nerve impairment in peroxisomal disorders.
    1. Neuroscience

    Dynamic representation of partially occluded objects in primate prefrontal and visual cortex

    Amber M Fyall et al.
    Complementary neural codes in frontal and visual cortex support a role for feedback signals in the representation and recognition of partially occluded objects.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Single-particle cryo-EM structure of a voltage-activated potassium channel in lipid nanodiscs

    Doreen Matthies et al.
    The structure of a voltage-activated potassium channel in lipid nanodiscs solved using cryo-electron microscopy is similar to previous X-ray structures, and provides insights into the mechanism of C-type inactivation.
    1. Neuroscience

    Optogenetically induced low-frequency correlations impair perception

    Anirvan Nandy et al.
    Low-frequency correlations among neurons in monkey visual area V4 impair the animal's ability to perform an attention-demanding task, suggesting a causal role of these fluctuations in perception.

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