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    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Evolutionary genomics of epidemic visceral leishmaniasis in the Indian subcontinent

    Hideo Imamura et al.
    Genome sequencing reveals the evolution and epidemiology of Leishmania donovani in the Indian subcontinent, where epidemics have caused up to 30,000 deaths per year.
    1. Neuroscience

    Altered potassium channel distribution and composition in myelinated axons suppresses hyperexcitability following injury

    Margarita Calvo et al.
    Type 1 potassium channels alter their composition and localisation to suppress hyper-excitability and neuropathic pain of injured sensory neurons.
    1. Neuroscience

    Analysis of protein phosphorylation in nerve terminal reveals extensive changes in active zone proteins upon exocytosis

    Mahdokht Kohansal-Nodehi et al.
    Global phosphoproteomic analysis in nerve terminal during exocytosis reveals 252 uniquely regulated phosphosites, highlighting complex regulation of active zone proteins at multiple sites and the role of specific kinases/phosphatases.
    1. Neuroscience

    Restoration of Mecp2 expression in GABAergic neurons is sufficient to rescue multiple disease features in a mouse model of Rett syndrome

    Kerstin Ure et al.
    Genetically restoring Mecp2 expression only in GABAergic neurons in a mouse model of Rett syndrome improves inhibitory signaling, extends lifespan and rescues most but not all behavioral deficits.
    1. Neuroscience

    Similar GABAA receptor subunit composition in somatic and axon initial segment synapses of hippocampal pyramidal cells

    Katalin Kerti-Szigeti, Zoltan Nusser
    All perisomatic GABAergic synpases on hippocampal pyramidal cells have a similar GABAA receptor subunit composition.
    1. Neuroscience

    Cellular resolution circuit mapping with temporal-focused excitation of soma-targeted channelrhodopsin

    Christopher A Baker et al.
    Combining spatial restriction of channelrhodopsin to the neuronal cell body with two photon excitation and calcium imaging will enable production of high resolution maps of neural circuitry.
    1. Cell Biology

    Histidine phosphorylation relieves copper inhibition in the mammalian potassium channel KCa3.1

    Shekhar Srivastava et al.
    The mammalian potassium channel KCa3.1, which is important for T- and B-cell activation, is inhibited by cytoplasmic copper, mediated by a histidine residue (His358) that is phosphorylated to activate the channel.
    1. Computational and Systems Biology
    2. Neuroscience

    Stochastic and deterministic dynamics of intrinsically irregular firing in cortical inhibitory interneurons

    Philipe RF Mendonça et al.
    A-type potassium conductances influence the distinctive firing behaviour of irregular-spiking interneurons.
    1. Neuroscience

    Sexually dimorphic neuronal responses to social isolation

    Laura Senst et al.
    Male and female mice react differently to social isolation but not to an acute physical stress.
    1. Structural Biology and Molecular Biophysics

    Fatty acid analogue N-arachidonoyl taurine restores function of IKs channels with diverse long QT mutations

    Sara I Liin et al.
    Fatty acid analogues are interesting prototype compounds that may inspire the development of future IKs channel activators to treat patients with long QT syndrome caused by diverse arrhythmia-causing mutations in the IKs channel.