61 results found
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Reformulation of an extant ATPase active site to mimic ancestral GTPase activity reveals a nucleotide base requirement for function

    Taylor B Updegrove et al.
    Reengineering the nucleotide-binding pocket of an extant ATPase to restore ancestral GTPase activity revealed an ATP-dependent intermediate required for function and suggested why the protein evolved to use ATP.
    1. Cell Biology
    2. Neuroscience

    TDP-43 maximizes nerve conduction velocity by repressing a cryptic exon for paranodal junction assembly in Schwann cells

    Kae-Jiun Chang et al.
    Glial TDP-43 regulates splicing and expression of neurofascin and is required for proper assembly and maintenance of paranodal axoglial junctions.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Dyshomeostatic modulation of Ca2+-activated K+ channels in a human neuronal model of KCNQ2 encephalopathy

    Dina Simkin et al.
    An inducedpluripotent stem cell (iPSC)-based model of KCNQ2-associated developmental epileptic encephalopathy suggests that disease is driven by dyshomeostaic neuronal mechanisms that are downstream of loss of M-current.
    1. Neuroscience

    Cold-induced hyperphagia requires AgRP neuron activation in mice

    Jennifer D Deem et al.
    A combination of neuroscience approaches and indirect calorimetry demonstrate a physiological role for AgRP neurons in cold-induced hyperphagia and strongly suggest temperature is an important regulator of AgRP neuron activity.
    1. Neuroscience

    How many neurons are sufficient for perception of cortical activity?

    Henry WP Dalgleish et al.
    Targeted optogenetic activation of small ensembles of neurons is sufficient to trigger a behavioral report while recruiting matched network suppression, suggesting exquisite sensitivity despite network mechanisms that maintain sparseness.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Control of Slc7a5 sensitivity by the voltage-sensing domain of Kv1 channels

    Shawn M Lamothe et al.
    The voltage-sensing mechanism of a subfamily of potassium channels is modulated in unconventional ways by an amino acid transporter.
    1. Neuroscience

    The palmitoyl acyltransferase ZDHHC14 controls Kv1-family potassium channel clustering at the axon initial segment

    Shaun S Sanders et al.
    ZDHHC14 controls palmitoylation and axon initial segment targeting of PSD93 and Kv1-family potassium channels, events that are essential for normal neuronal excitability.
    1. Neuroscience

    Purkinje cell neurotransmission patterns cerebellar basket cells into zonal modules defined by distinct pinceau sizes

    Joy Zhou et al.
    Targeted genetic silencing and reporter labeling reveal that Purkinje cell activity organizes cerebellar basket cells into zonal modules based on the sizes of their projections.
    1. Neuroscience

    Neurofascin and Kv7.3 are delivered to somatic and axon terminal surface membranes en route to the axon initial segment

    Aniket Ghosh et al.
    Neuronal neurofascin takes a surprisingly circuitous route in the neuronal plasma membrane to the axon initial segment where it stabilises ion channel complexes responsible for initiating action potentials.
    1. Developmental Biology

    DAZL mediates a broad translational program regulating expansion and differentiation of spermatogonial progenitors

    Maria M Mikedis et al.
    DAZL promotes male fertility by enhancing the protein expression of thousands of genes to facilitate expansion and differentiation of transit-amplifying spermatogonia in the testes.

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