16,155 results found
    1. Neuroscience

    Dissociable laminar profiles of concurrent bottom-up and top-down modulation in the human visual cortex

    Samuel JD Lawrence, David G Norris, Floris P de Lange
    Neural activity in the visual system is increased in different layers of the neocortex for bottom-up and top-down modulations.
    1. Neuroscience

    Statistical learning attenuates visual activity only for attended stimuli

    David Richter, Floris P de Lange
    Prior expectations, induced by statistical learning, affect sensory processing only for attended stimuli, thereby constraining neurocomputational theories that cast perception as an inferential process integrating prior knowledge and sensory evidence.
    1. Plant Biology

    Uncovering natural variation in root system architecture and growth dynamics using a robotics-assisted phenomics platform

    Therese LaRue, Heike Lindner ... José R Dinneny
    Advances in robotics-assisted plant handling and automated image analysis enables the characterization of root growth dynamics for Arabidopsis accessions at late stages of development and the association of these traits with genetic variation and climatic variables.
    1. Neuroscience

    Successor-like representation guides the prediction of future events in human visual cortex and hippocampus

    Matthias Ekman, Sarah Kusch, Floris P de Lange
    Early visual cortex (V1) and hippocampal cortex represent a predictive map of the visual world akin to the successor representation.
    1. Neuroscience

    THINGS-data, a multimodal collection of large-scale datasets for investigating object representations in human brain and behavior

    Martin N Hebart, Oliver Contier ... Chris I Baker
    THINGS-data reflects three large-scale neuroimaging and behavioral datasets of object processing in humans, comprising densely sampled functional MRI and magnetoencephalographic recordings, as well as 4.70 million similarity judgments in response to thousands of photographic images for up to 1854 objects.
    1. Neuroscience

    Presynaptic NMDARs cooperate with local spikes toward GABA release from the reciprocal olfactory bulb granule cell spine

    Vanessa Lage-Rupprecht, Li Zhou ... Veronica Egger
    The essential role of presynaptic NMDA receptors for granule cell GABAergic output elucidates the function of reciprocal spines in recurrent and possibly lateral inhibition of mitral cells during olfactory processsing.
    1. Cancer Biology

    TINF2 is a haploinsufficient tumor suppressor that limits telomere length

    Isabelle Schmutz, Arjen R Mensenkamp ... Titia de Lange
    Mutations in TIN2, a component of shelterin that keeps telomere length in check, lead to cancer-predisposition by disabling the telomere tumor suppressor pathway.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Molecular determinants of large cargo transport into the nucleus

    Giulia Paci, Tiantian Zheng ... Edward A Lemke
    Efficient nuclear transport of very large biomolecules, relevant for viral transport, scales non-linearly with size and its kinetics can be explained by a simple two-parameter energetic model.
    1. Biochemistry and Chemical Biology
    2. Developmental Biology

    The major β-catenin/E-cadherin junctional binding site is a primary molecular mechano-transductor of differentiation in vivo

    Jens-Christian Röper, Démosthène Mitrossilis ... Emmanuel Farge
    The primary molecular mechanosensor involved in a physiological process of mechanically induced cell fate differentiation is revealed here for the first time in vivo, highly sensitive and potentially shared by all metazoan epithelia.
    1. Neuroscience

    Mechanisms of distributed working memory in a large-scale network of macaque neocortex

    Jorge F Mejías, Xiao-Jing Wang
    An anatomically constrained computational model of the macaque cortical network demonstrates the emergence of large-scale distributed patterns of mnemonic activity sustained by long-range cortico-cortical interactions.

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