27 results found
    1. Genetics and Genomics
    2. Medicine

    Association of Toll-like receptor 7 variants with life-threatening COVID-19 disease in males: findings from a nested case-control study

    Chiara Fallerini et al.
    In the context of susceptibility to severe COVID-19, the observations of a study provide the basis for a personalized interferon-based therapy in patients with rare TLR7 variants.
    1. Cell Biology
    2. Developmental Biology

    Physically asymmetric division of the C. elegans zygote ensures invariably successful embryogenesis

    Radek Jankele et al.
    Systematic analysis of C. elegans zygotes manipulated to divide equally demonstrates that daughter cell size asymmetry is critical for proper cell cycle timing, positioning, and fates during subsequent embryogenesis.
    1. Genetics and Genomics
    2. Medicine

    COVID-19: Rare variants increase the risk of severe COVID-19

    Frank L van de Veerdonk, Mihai G Netea
    Evidence is mounting that rare loss-of-function variants in the TLR7 gene predispose men with no medical history to severe forms of COVID-19.
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    1. Cell Biology
    2. Computational and Systems Biology

    Identifying molecular features that are associated with biological function of intrinsically disordered protein regions

    Taraneh Zarin et al.
    A statistical model systematically associates functions of intrinsically disordered regions with sequence-distributed molecular features such as charge, residue composition, or repeat content.
    1. Cell Biology
    2. Computational and Systems Biology

    Active machine learning-driven experimentation to determine compound effects on protein patterns

    Armaghan W Naik et al.
    In an investigation into the effects of drugs on proteins, an active machine learning algorithm chose which sets of experiments to perform and was able to learn an accurate model of the effects after doing only a fraction of the experiments.
    1. Neuroscience

    Characterizing a psychiatric symptom dimension related to deficits in goal-directed control

    Claire M Gillan et al.
    A dimensional approach to psychiatry demonstrates the specificity and generalizability of a neurocognitive marker of compulsive behavior and intrusive thought via large-scale online testing.
    1. Epidemiology and Global Health
    2. Immunology and Inflammation

    A single, continuous metric to define tiered serum neutralization potency against HIV

    Peter Hraber et al.
    To quantify serum or antibody activity against HIV-1, logistic regression of single-dilution neutralization outcomes can efficiently summarize neutralization potency and indicate which samples may lack sufficient statistical support, for high-throughput screening in large-scale vaccine trials.
    1. Neuroscience

    An approach for long-term, multi-probe Neuropixels recordings in unrestrained rats

    Thomas Zhihao Luo et al.
    Techniques are presented to facilitate widespread and standardized chronic use of Neuropixels probes for high-yield, long-term neural recording in freely moving animals.
    1. Neuroscience

    Value generalization in human avoidance learning

    Agnes Norbury et al.
    Individual differences in generalization of aversive value (but not safety information) during human active avoidance learning specifically predict experience of anxiety and intrusive thoughts.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Dengue genetic divergence generates within-serotype antigenic variation, but serotypes dominate evolutionary dynamics

    Sidney M Bell et al.
    Each dengue serotype contains moderate antigenic diversity, and population immunity drives clade turnover in a hyperendemic population.

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