8,908 results found
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Precise let-7 expression levels balance organ regeneration against tumor suppression

    Linwei Wu et al.
    Mouse genetic studies reveal that let-7 performs potent tumor suppressive roles, but at the expense of regeneration and tissue homeostasis in the liver, findings with unanticipated therapeutic implications.
    1. Neuroscience

    Perception in autism does not adhere to Weber’s law

    Bat-Sheva Hadad, Sivan Schwartz
    Perception in autism is sensitive to absolute rather than to relative metrics of the environment, encoding changes in the environment without calibrating the changes relative to reference stimulation.
    1. Neuroscience

    Reinforcement biases subsequent perceptual decisions when confidence is low, a widespread behavioral phenomenon

    Armin Lak et al.
    Confidence-dependent reinforcement learning is active and produces trial-to-trial choice updating even in well-learned perceptual decisions without explicit reward biases, across species and sensory modalities.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    TRF1 averts chromatin remodelling, recombination and replication dependent-break induced replication at mouse telomeres

    Rosa Maria Porreca et al.
    TRF1 suppresses replication fork stalling, which triggers break induced replication at telomeres associated with DNA damage response, alteration in the telomere chromatin environment, and re-localisation of telomeres to PML bodies.
    1. Genetics and Genomics
    2. Plant Biology

    The Arabidopsis active demethylase ROS1 cis-regulates defence genes by erasing DNA methylation at promoter-regulatory regions

    Thierry Halter et al.
    Active DNA demethylation at some defence gene promoters is causal for DNA binding of WRKY transcription factors as well as for transcriptional activation of these genes during plant immune response.
    1. Neuroscience

    Emergence of transformation-tolerant representations of visual objects in rat lateral extrastriate cortex

    Sina Tafazoli et al.
    Neuronal recordings from rat visual cortex reveal an object-processing pathway, along which neuronal representations become increasingly capable of supporting recognition of visual objects in spite of variation in their appearance.
    1. Chromosomes and Gene Expression

    HIV Tat controls RNA Polymerase II and the epigenetic landscape to transcriptionally reprogram target immune cells

    Jonathan E Reeder et al.
    Tat uses unexpected regulatory mechanisms to reprogram target immune cells to promote viral replication and rewire pathways beneficial for HIV.
    1. Cell Biology

    Phosphorylation of β-arrestin2 at Thr383 by MEK underlies β-arrestin-dependent activation of Erk1/2 by GPCRs

    Elisabeth Cassier et al.
    Phosphoproteomics identifies β-arrestin 2 phosphorylation at Thr383 by MEK as a key step of GPCR-induced Erk½ activation, thus providing new insight into the molecular mechanism underlying β-arrestin-dependent GPCR-operated signaling.
    1. Cell Biology
    2. Neuroscience

    Sensing of nutrients by CPT1C regulates late endosome/lysosome anterograde transport and axon growth

    Marta Palomo-Guerrero et al.
    The pseudoenzyme CPT1C is able to sense changes in intracellular malonyl-CoA levels caused by nutrients or energy stress and regulate late endosomes/lysosomes anterograde transport, necessary for proper axon growth.
    1. Cancer Biology

    Dissecting cell-type-specific metabolism in pancreatic ductal adenocarcinoma

    Allison N Lau et al.
    Isotope tracing into macromolecules enables functional analysis of metabolism in specific cell populations in tumors and provides insight into metabolic differences between cancer and stromal cells in their endogenous microenvironment.

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