1,078 results found
    1. Neuroscience

    Misaligned feeding impairs memories

    Dawn H Loh et al.
    The time at which mice consume food can dramatically affect hippocampal-dependent biochemistry, physiology, and learned behavior.
    1. Cell Biology

    Nuclear receptor LRH-1/NR5A2 is required and targetable for liver endoplasmic reticulum stress resolution

    Jennifer L Mamrosh et al.
    LRH-1/NR5A2 responds to ER stress by inducing a novel pathway that is required for stress resolution in mice and can be targeted by LRH-1 agonists.
    1. Chromosomes and Gene Expression
    2. Plant Biology

    DDM1 and Lsh remodelers allow methylation of DNA wrapped in nucleosomes

    David B Lyons, Daniel Zilberman
    Nucleosomes and linker histones block eukaryotic cytosine methylation.
    1. Structural Biology and Molecular Biophysics
    2. Evolutionary Biology

    An atomic-resolution view of neofunctionalization in the evolution of apicomplexan lactate dehydrogenases

    Jeffrey I Boucher et al.
    The convergent evolution of unusually strict substrate specificity in apicomplexan LDHs arose by classic neofunctionalization of a duplicated MDH gene via few mutations of large effect.
    1. Cell Biology

    A conserved LDL-receptor motif regulates corin and CD320 membrane targeting in polarized renal epithelial cells

    Ce Zhang et al.
    A conserved motif in corin and CD320 LDL receptor modules regulates specific apical trafficking in polarized renal epithelial cells.
    1. Cell Biology

    BLOS1 mediates kinesin switch during endosomal recycling of LDL receptor

    Chang Zhang et al.
    BLOS1 is a new regulator of LDLR endosomal recycling through coordinating kinesins during long-range transport, and depletion of BLOS1 in mouse liver leads to aberrant lipid metabolism.
    1. Cell Biology
    2. Neuroscience

    RNA binding protein Caprin-2 is a pivotal regulator of the central osmotic defense response

    Agnieszka Konopacka et al.
    Caprin-2 is up-regulated in the rat hypothalamus by osmotic stress and controls vital homeostatic osmoregulatory mechanisms by altering the length of the poly(A) tail on arginine vasopressin mRNAs.
    1. Structural Biology and Molecular Biophysics
    2. Developmental Biology

    An ancient Pygo-dependent Wnt enhanceosome integrated by Chip/LDB-SSDP

    Marc Fiedler et al.
    The Chip/LDB-SSDP complex integrates multiple signals to render TCF/LEF enhancers Wnt responsive.
    1. Cell Biology

    A gene-expression screen identifies a non-toxic sumoylation inhibitor that mimics SUMO-less human LRH-1 in liver

    Miyuki Suzawa et al.
    The FDA-approved compound and plant extract tannic acid is a non-toxic chemical tool for modulating sumoylation in multiple platforms.

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