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    1. Neuroscience

    Atoh1-dependent rhombic lip neurons are required for temporal delay between independent respiratory oscillators in embryonic mice

    Srinivasan Tupal et al.
    The rhythmic patterns of activity that underlie breathing are generated and coordinated by distinct populations of neurons within the brainstem.
    1. Developmental Biology
    2. Neuroscience

    The Makorin lep-2 and the lncRNA lep-5 regulate lin-28 to schedule sexual maturation of the C. elegans nervous system

    Hannah Lawson et al.
    Genes implicated in the control of mammalian puberty function as components of a molecular clock that determines the timing of sexual differentiation in the C. elegans nervous system.
    1. Neuroscience

    Microglia TREM2R47H Alzheimer-linked variant enhances excitatory transmission and reduces LTP via increased TNF-α levels

    Siqiang Ren et al.
    Analysis of rats carrying the microglia gene and Alzheimer risk factor Trem2R47H variant shows increased glutamatergic transmission via supraphysiological TNF-α brain concentrations, linking a microglia pathogenic variant to neuronal dysfunction.
    1. Cell Biology
    2. Neuroscience

    Mitochondrial support of persistent presynaptic vesicle mobilization with age-dependent synaptic growth after LTP

    Heather L Smith et al.
    Three-dimensional electron microscopy (3DEM) demonstrates the dependence on presynaptic mitochondria for vesicle mobilization as dendritic spines are silently added at P15 or synapses are silently enlarged in adults after long-term potentiation.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Reduced expression of C/EBPβ-LIP extends health and lifespan in mice

    Christine Müller et al.
    Reduced expression of a single transcription factor is sufficient to improve fitness and health at old age and increases the lifespan in female mice.
    1. Neuroscience

    A neural mechanism of speed-accuracy tradeoff in macaque area LIP

    Timothy Hanks et al.
    To establish a trade-off between the speed and accuracy of a decision, neurons in lateral intraparietal cortex combine evidence bearing on the decision with a signal that incorporates the cost of time into the decision-making process.
    1. Neuroscience

    Structural plasticity of dendritic secretory compartments during LTP-induced synaptogenesis

    Yelena D Kulik et al.
    The secretory and recycling components of neuronal dendrites, smooth endoplasmic reticulum and endosomes, were discovered to support synaptogenesis underlying a cellular mechanism of learning and memory in the developing brain.
    1. Neuroscience

    LTP and memory impairment caused by extracellular Aβ and Tau oligomers is APP-dependent

    Daniela Puzzo et al.
    Oligomeric Amyloid-β and Tau, two proteins involved in Alzheimer's disease pathogenesis, require Amyloid Precursor Protein to enter neurons and exert their detrimental effect on synaptic plasticity and memory.
    1. Neuroscience

    Sleep-active neuron specification and sleep induction require FLP-11 neuropeptides to systemically induce sleep

    Michal Turek et al.
    The mechanisms of specification and sleep induction by the single sleep-active neuron are revealed in C. elegans.