816 results found
    1. Human Biology and Medicine

    Expression of SREBP-1c Requires SREBP-2-mediated Generation of a Sterol Ligand for LXR in Livers of Mice

    Shunxing Rong et al.
    SREBP-2 directly regulates genes involved in cholesterol homeostasis and indirectly regulates fatty acid synthesis through the production of a ligand responsible for the activation of LXR and SREBP-1c.
    1. Cell Biology
    2. Developmental Biology and Stem Cells

    R-spondins can potentiate WNT signaling without LGRs

    Andres M Lebensohn, Rajat Rohatgi
    R-spondins 2 and 3 can potentiate WNT signaling in the absence of LGRs through interactions with ZNRF3/RNF43 E3 ubiquitin ligases and heparan sulfate proteoglycans, defining two alternative modes of R-spondin-mediated signaling.
    1. Cell Biology
    2. Genes and Chromosomes

    LXRs link metabolism to inflammation through Abca1-dependent regulation of membrane composition and TLR signaling

    Ayaka Ito et al.
    The cholesterol-sensing nuclear receptor LXR regulates inflammatory responses by altering the lipid composition of cell membranes.
    1. Cell Biology

    Inhibition of cholesterol biosynthesis through RNF145-dependent ubiquitination of SCAP

    Li Zhang et al.
    The E3 ubiquitin ligase RNF145 is shown to contribute to crosstalk between the LXR and SREBP-2 pathways in the regulation of cholesterol homeostasis.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Aberrant corticosteroid metabolism in tumor cells enables GR takeover in enzalutamide resistant prostate cancer

    Jianneng Li et al.
    Prostate cancer resistance to androgen receptor antagonist therapy occurs by way of tumors impeding local glucocorticoid metabolism and inactivation and thereby permitting sustained glucocorticoids to stimulate up-regulated glucocorticoid receptor.
    1. Cell Biology
    2. Developmental Biology and Stem Cells

    Egr-5 is a post-mitotic regulator of planarian epidermal differentiation

    Kimberly C Tu et al.
    The dynamic homeostasis of the planarian epidermis serves as an experimental paradigm to study stem cell dynamics and post-mitotic specification of diverse functional cell fates.
    1. Neuroscience

    AMPK acts as a molecular trigger to coordinate glutamatergic signals and adaptive behaviours during acute starvation

    Moloud Ahmadi, Richard Roy
    AMP-activated protein kinase directly coordinates glutamatergic signalling during starvation in C. elegans.
    1. Biochemistry and Chemical Biology

    A dynamic RNA loop in an IRES affects multiple steps of elongation factor-mediated translation initiation

    Marisa D Ruehle et al.
    During initiation factor-independent RNA structure-driven translation initiation, a flexible RNA element drives the movement of a viral IRES through the ribosome's tRNA binding sites and promotes tRNA binding.
    1. Cell Biology
    2. Neuroscience

    The unfolded protein response is required for dendrite morphogenesis

    Xing Wei et al.
    The unfolded protein response regulates neuronal dendrite morphogenesis by controlling the folding of a transmembrane leucine-rich repeat (LRR) protein.
    1. Biochemistry and Chemical Biology
    2. Human Biology and Medicine

    The functional O-mannose glycan on α-dystroglycan contains a phospho-ribitol primed for matriglycan addition

    Jeremy L Praissman et al.
    Disruption of the LG domain-binding phospho-ribitol-containing O-mannose structures on α-dystroglycan results in congenital muscular dystrophy.

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