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    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Role of the pre-initiation complex in Mediator recruitment and dynamics

    Elisabeth R Knoll et al.
    Genome-wide recruitment of Mediator and Pol II is reduced in yeast lacking the Med2-Med3-Med15 tail module triad, and Mediator association with gene promoters depends on Pol II, Taf1, and TBP.
    1. Neuroscience

    Timing mechanism of sexually dimorphic nervous system differentiation

    Laura Pereira et al.
    The timing of sexual differentiation in the brain of the nematode Caenorhabditis elegans is controlled by a phylogenetically conserved pathway of gene regulatory factors.
    1. Developmental Biology
    2. Medicine

    CHARGE syndrome modeling using patient-iPSCs reveals defective migration of neural crest cells harboring CHD7 mutations

    Hironobu Okuno et al.
    Neural crest cells differentiated from patient-derived cells with mutations in the chromatin remodeler CHD7 show defective delamination, migration and motility in vitro, and defective migration in chick embryos.
    1. Immunology and Inflammation

    Modulation of let-7 miRNAs controls the differentiation of effector CD8 T cells

    Alexandria C Wells et al.
    TCR-mediated downregulation of let-7 microRNAs licenses the differentiation of activated CD8 T cells into cytotoxic T lymphocytes.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Cytoplasmic dynein crosslinks and slides anti-parallel microtubules using its two motor domains

    Marvin E Tanenbaum et al.
    The motor domains of dynein are sufficient to crosslink microtubules and slide them antiparallel to each other.
    1. Developmental Biology

    An essential role for maternal control of Nodal signaling

    Pooja Kumari et al.
    Regulation of conserved Nodal factors by a maternal protein ensures that Nodal signaling is repressed until the appropriate time in embryonic development.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    16p11.2 microdeletion imparts transcriptional alterations in human iPSC-derived models of early neural development

    Julien G Roth et al.
    A model of in vitro human corticogenesis identifies alterations in gene expression caused by loss of 16p11.2 CNV genes in hiPSC-derived progenitor cells.
    1. Chromosomes and Gene Expression

    The Fml1-MHF complex suppresses inter-fork strand annealing in fission yeast

    Io Nam Wong et al.
    Genomic deletions formed from inter-fork strand annealing associated with a collapsed replication fork are suppressed by the FANCM-related DNA helicase Fml1 in conjunction with its partner proteins Mhf1 and Mhf2.
    1. Cell Biology

    The mammalian LINC complex component SUN1 regulates muscle regeneration by modulating drosha activity

    Tsui Han Loo et al.
    The LINC complex, that couples the interphase cytoskeleton to the nucleus, regulates the processing of a cluster of miRNAs required for muscle regeneration by recruiting and interacting directly with Drosha.
    1. Developmental Biology
    2. Neuroscience

    A counter gradient of Activin A and follistatin instructs the timing of hair cell differentiation in the murine cochlea

    Meenakshi Prajapati-DiNubila et al.
    Opposing gradients of activin A and follistatin within the spiral shaped mammalian cochlea instruct the graded pattern of mechano-sensory hair cell formation.