953 results found
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Characterization of sequence determinants of enhancer function using natural genetic variation

    Marty G Yang, Emi Ling ... Thomas Vierbuchen
    Large-scale, allele-resolved mapping of cis-regulatory function in F1-hybrid mice reveals sequence determinants that control transcription factor binding and enhancer activity in native chromatin context.
    1. Neuroscience

    Overriding FUS autoregulation in mice triggers gain-of-toxic dysfunctions in RNA metabolism and autophagy-lysosome axis

    Shuo-Chien Ling, Somasish Ghosh Dastidar ... Don W Cleveland
    Elevating FUS level by saturating autoregulation loop in mice causes aggressive motor neuron disease via disrupting protein and RNA homeostasis.
    1. Plant Biology

    Proximity labeling of protein complexes and cell-type-specific organellar proteomes in Arabidopsis enabled by TurboID

    Andrea Mair, Shou-Ling Xu ... Dominique C Bergmann
    Proximity-labeling using engineered biotin ligases TurboID and miniTurbo enables detection of cell-type-specific and low abundance protein complexes and subcellular proteomes in Arabidopsis and other plants.
    1. Neuroscience

    Lip movements entrain the observers’ low-frequency brain oscillations to facilitate speech intelligibility

    Hyojin Park, Christoph Kayser ... Joachim Gross
    Rhythms of lip movements entrain low-frequency brain oscillations and facilitate audiovisual speech processing.
    1. Ecology

    Warming and altered precipitation independently and interactively suppress alpine soil microbial growth in a decadal-long experiment

    Yang Ruan, Ning Ling ... Zhibiao Nan
    Warming and altered precipitation reduce the growth rates of alpine soil bacteria by 40-90%, and the growth of ~70% taxa is influenced by antagonistic interactions between factors.
    1. Cancer Biology

    LIPG signaling promotes tumor initiation and metastasis of human basal-like triple-negative breast cancer

    Pang-Kuo Lo, Yuan Yao ... Qun Zhou
    LIPG, a lipoprotein lipase, executes its oncogenic function in human basal-like triple-negative breast cancer through its functional involvement in DTX3L-ISG15 signaling, an interferon-related pathway that regulates protein functionality by ISGylation.
    1. Developmental Biology

    Stage-specific control of oligodendrocyte survival and morphogenesis by TDP-43

    Dongeun Heo, Jonathan P Ling ... Dwight E Bergles
    Loss of the RNA-binding protein TDP-43 impairs the survival of oligodendrocyte progenitors and reactivates growth of mature oligodendrocytes, resulting in inappropriate wrapping of neuronal somata and blood vessels.
    1. Neuroscience

    Atoh1-dependent rhombic lip neurons are required for temporal delay between independent respiratory oscillators in embryonic mice

    Srinivasan Tupal, Wei-Hsiang Huang ... Paul A Gray
    The rhythmic patterns of activity that underlie breathing are generated and coordinated by distinct populations of neurons within the brainstem.
    1. Developmental Biology

    Overburdened ferroptotic stress impairs tooth morphogenesis

    Haisheng Wang, Xiaofeng Wang ... Ling Ye
    The accumulation of ferroptotic stress during tooth development has a critical effect on its morphogenesis.
    1. Ecology

    A moth odorant receptor highly expressed in the ovipositor is involved in detecting host-plant volatiles

    Rui-Ting Li, Ling-Qiao Huang ... Chen-Zhu Wang
    A moth can detect plant volatiles using an odorant receptor expressing in its ovipositor, and this odorant receptor has a much higher expression level in the ovipositor than antennae.

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