Membrane atg8ylation but not canonical autophagy control retromer-dependent endosomal sorting of cargo, including glucose transporter GLUT1, of general import and of significance for control of tuberculosis.

A genetic approach in Caenorhabditis elegans shows that the cleaved and cytosolic form of the ubiquitin-like protein LGG-1/GABARAP is sufficient for both autophagy and embryonic development.

cis-membrane insertion of human ATG8 N-terminus facilitates autophagosome membrane expansion independent of autophagic cargo.

Transcription factor Zbtb14 plays an important role in monocyte and macrophage development through the modulation of pu.1 expression.

Fluorescence fluctuation spectroscopy is implemented for detection of up to four molecular species, allowing users to quantify molecular interactions and stoichiometry of multicomponent complexes in live cells, in a wide range of biological processes, from membrane signaling to viral assembly.

A combination of spatial proteomic and autophagic flux approaches was used to reveal the landscape of turnover of damaged lysosomes, demonstrating a key role for the autophagy receptor TAX1BP1 and its associated kinase TBK1 in both HeLa cells and iNeurons.

WASp is an immunometabolic regulator of human myeloid cells and regulates autophagy and mitochondrial homeostasis.

Atg43 serves as a selective autophagy receptor by tethering isolation membranes to mitochondria to promote mitophagy and plays a mitophagy-independent role that facilitates normal cell growth in fission yeast.

C53 bridges selective autophagy with ribosome-associated quality control at the endoplasmic reticulum.

Hydrogen-deuterium exchange, electron microscopy, and vesicle reconstitution show how binding of the autophagy adaptor NDP52 to the FIP200 subunit of the ULK1 complex triggers membrane binding in autophagy.