1,926 results found
    1. Cell Biology
    2. Developmental Biology

    The GNU subunit of PNG kinase, the developmental regulator of mRNA translation, binds BIC-C to localize to RNP granules

    Emir E Avilés-Pagán et al.
    The Drosophila PNG kinase controls mRNA translation at the oocyte-to-embryo transition, and its GNU activating subunit is shown here to bind translational repressors and be a component of RNP granules.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    HOXA9 promotes MYC-mediated leukemogenesis by maintaining gene expression for multiple anti-apoptotic pathways

    Ryo Miyamoto et al.
    HOXA9 is a transcriptional maintenance factor for anti-apoptotic genes that accelerate MYC-driven leukemia.
    1. Microbiology and Infectious Disease

    In vivo imaging of retrovirus infection reveals a role for Siglec-1/CD169 in multiple routes of transmission

    Kelsey A Haugh et al.
    Retroviruses exploit the lectin, Siglec-1/CD169, expressed on sentinel macrophages to promote infection during multiple routes of transmission.
    1. Neuroscience

    A locomotor neural circuit persists and functions similarly in larvae and adult Drosophila

    Kristen Lee, Chris Q Doe
    Descending interneurons maintain synaptic connectivity and behavioral function despite pruning during metamorphosis, showing that synaptic specificity is established twice at different life stages.
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    CTP promotes efficient ParB-dependent DNA condensation by facilitating one-dimensional diffusion from parS

    Francisco de Asis Balaguer et al.
    Single-molecule methods reveal that cytidine triphosphate promotes DNA condensation specifically at bacterial centromeres by facilitating one-dimensional diffusion of ParB from parS sites.
    1. Neuroscience

    Information flow, cell types and stereotypy in a full olfactory connectome

    Philipp Schlegel et al.
    Synaptic resolution analysis of a full olfactory connectome reveals lateralised circuits, convergence of innate and learned pathways, and shows that homologous neurons are highly stereotyped within and across brains.
    1. Cell Biology
    2. Neuroscience

    Miro1-dependent mitochondrial dynamics in parvalbumin interneurons

    Georgina Kontou et al.
    Cell imaging and electrophysiology in the mouse hippocampus reveal a crucial role for the spatiotemporal regulation of mitochondrial dynamics in PV+ interneurons on cell morphology, network activity, and behavior.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Introgression shapes fruit color convergence in invasive Galápagos tomato

    Matthew JS Gibson et al.
    A wild tomato species adopts local fruit color via introgression from an endemic relative, during its invasion onto the Galápagos Islands.
    1. Neuroscience
    2. Physics of Living Systems

    The neuronal calcium sensor Synaptotagmin-1 and SNARE proteins cooperate to dilate fusion pores

    Zhenyong Wu et al.
    During neurotransmitter release, calcium-induced membrane insertion of the C2B domain of Synaptotagmin re-orients the bound SNARE complex which dilates the fusion pore in a mechanical lever action.
    1. Cell Biology
    2. Neuroscience

    Sorting nexin-27 regulates AMPA receptor trafficking through the synaptic adhesion protein LRFN2

    Kirsty J McMillan et al.
    An unbiased proteomic approach identifies a new regulator of AMPA receptor trafficking providing additional insight into synaptic transmission and plasticity.

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