Browse the search results

Page 2 of 188
    1. Structural Biology and Molecular Biophysics

    Voltage-clamp fluorometry analysis of structural rearrangements of ATP-gated channel P2X2 upon hyperpolarization

    Rizki Tsari Andriani, Yoshihiro Kubo
    A fluorometric analysis under voltage clamp shows the presence of a converged electric field in P2X2 channel with no canonical voltage-sensor and identifies the structural determinants for the voltage-dependent gating.
    1. Ecology
    2. Evolutionary Biology

    Pleiotropic mutations can rapidly evolve to directly benefit self and cooperative partner despite unfavorable conditions

    Samuel Frederick Mock Hart et al.
    Mutations that directly benefit both self and cooperative partner can readily evolve to promote cooperation.
    1. Microbiology and Infectious Disease

    Erythrocyte CD55 mediates the internalization of Plasmodium falciparum parasites

    Bikash Shakya et al.
    The strain-transcendent receptor CD55 plays a distinct functional role relative to other known receptors for Plasmodium falciparum invasion of human erythrocytes, indicating it may present a vulnerable target for intervention.
    1. Cell Biology
    2. Developmental Biology

    Single-cell transcriptome analysis defines heterogeneity of the murine pancreatic ductal tree

    Audrey M Hendley et al.
    Single-cell RNA-sequencing analyses and functional studies define heterogeneity within the pancreatic ductal tree and unique properties of subpopulations of duct cells including an epithelial-mesenchymal transcriptomic axis and roles in chronic pancreatic inflammation.
    1. Evolutionary Biology
    2. Physics of Living Systems

    Functional biology in its natural context: A search for emergent simplicity

    Joy Bergelson et al.
    The time is right to study biological function without stripping systems of their essential eco-evolutionary context.
    1. Neuroscience

    Metal microdrive and head cap system for silicon probe recovery in freely moving rodent

    Mihály Vöröslakos et al.
    A reusable system of 3D printed stainless steel microdrive and plastic head cap allows stable recording of electrophysiological data in mice and rats and easy recovery of silicon probes.
    1. Neuroscience

    Optogenetic strategies for high-efficiency all-optical interrogation using blue-light-sensitive opsins

    Angelo Forli et al.
    A new soma-targeted variant of the large-conductance blue-light-sensitive opsin CoChR combined with advanced optical stimulation methods allows high-efficiency all-optical neuronal imaging and stimulation in mouse brain in vivo.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    The critical role of Hedgehog-responsive mesenchymal progenitors in meniscus development and injury repair

    Yulong Wei et al.
    Meniscal Gli1+ cells are mesenchymal progenitors that contribute to the development and injury repair of meniscus.
    1. Neuroscience

    Unveiling the sensory and interneuronal pathways of the neuroendocrine connectome in Drosophila

    Sebastian Hückesfeld et al.
    Core of a neuroendocrine synaptic network consists of a parallel set of interneurons that target distinct combinations of neuroendocrine outputs, thus enabling variability and flexibility in selection of physiological activity.
    1. Cell Biology
    2. Immunology and Inflammation

    Tight nanoscale clustering of Fcγ receptors using DNA origami promotes phagocytosis

    Nadja Kern et al.
    Manipulating nanoscale spacing of Fcγ receptors using DNA origami demonstrates that ligand clustering regulates receptor phosphorylation and phagocytosis.