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    1. Neuroscience

    A locomotor neural circuit persists and functions similarly in larvae and adult Drosophila

    Kristen Lee, Chris Q Doe
    Descending interneurons maintain synaptic connectivity and behavioral function despite pruning during metamorphosis, showing that synaptic specificity is established twice at different life stages.
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    CTP promotes efficient ParB-dependent DNA condensation by facilitating one-dimensional diffusion from parS

    Francisco de Asis Balaguer et al.
    Single-molecule methods reveal that cytidine triphosphate promotes DNA condensation specifically at bacterial centromeres by facilitating one-dimensional diffusion of ParB from parS sites.
    1. Neuroscience

    Information flow, cell types and stereotypy in a full olfactory connectome

    Philipp Schlegel et al.
    Synaptic resolution analysis of a full olfactory connectome reveals lateralised circuits, convergence of innate and learned pathways, and shows that homologous neurons are highly stereotyped within and across brains.
    1. Cell Biology
    2. Neuroscience

    Miro1-dependent mitochondrial dynamics in parvalbumin interneurons

    Georgina Kontou et al.
    Cell imaging and electrophysiology in the mouse hippocampus reveal a crucial role for the spatiotemporal regulation of mitochondrial dynamics in PV+ interneurons on cell morphology, network activity, and behavior.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Introgression shapes fruit color convergence in invasive Galápagos tomato

    Matthew JS Gibson et al.
    A wild tomato species adopts local fruit color via introgression from an endemic relative, during its invasion onto the Galápagos Islands.
    1. Neuroscience
    2. Physics of Living Systems

    The neuronal calcium sensor Synaptotagmin-1 and SNARE proteins cooperate to dilate fusion pores

    Zhenyong Wu et al.
    During neurotransmitter release, calcium-induced membrane insertion of the C2B domain of Synaptotagmin re-orients the bound SNARE complex which dilates the fusion pore in a mechanical lever action.
    1. Cell Biology
    2. Neuroscience

    Sorting nexin-27 regulates AMPA receptor trafficking through the synaptic adhesion protein LRFN2

    Kirsty J McMillan et al.
    An unbiased proteomic approach identifies a new regulator of AMPA receptor trafficking providing additional insight into synaptic transmission and plasticity.
    1. Plant Biology

    Two NLR immune receptors acquired high-affinity binding to a fungal effector through convergent evolution of their integrated domain

    Aleksandra Białas et al.
    The HMA domains of Pikp-1 and Pikm-1 NLR receptors have convergently evolved to bind AVR-PikD with high affinity through distinct evolutionary and biochemical paths.
    1. Developmental Biology
    2. Genetics and Genomics

    Somatic aging pathways regulate reproductive plasticity in Caenorhabditis elegans

    Maria C Ow et al.
    Somatic aging and germline RNAi pathways promote inheritance of ancestral starvation memory through reallocation of fat storage in Caenorhabditis elegans.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Targeting an anchored phosphatase-deacetylase unit restores renal ciliary homeostasis

    Janani Gopalan et al.
    An anchored phosphatase-deacetylase complex participates in primary cilia development.