677 results found
    1. Neuroscience

    Distinct population code for movement kinematics and changes of ongoing movements in human subthalamic nucleus

    Dennis London et al.
    Subthalamic nucleus spiking activity, beta oscillation power, and locking of spikes to the beta oscillation are decreased prior to changes in ongoing movements.
    1. Genetics and Genomics
    2. Medicine

    SMA-miRs (miR-181a-5p, -324-5p, and -451a) are overexpressed in spinal muscular atrophy skeletal muscle and serum samples

    Emanuela Abiusi et al.
    The identification of SMA-miR supports the pathogenic role of skeletal muscle in spinal muscular atrophy and, integrated in the SMA-score, may help to improve the phenotypic prediction for patients.
    1. Cancer Biology

    Innate immune activation by checkpoint inhibition in human patient-derived lung cancer tissues

    Teresa WM Fan et al.
    Pembrolizumab activates innate immune metabolism and function in primary human non-small cell lung cancer, whereas Pembrolizumab and beta-glucan synergize in enhancing immune metabolism and tumoridical action in brain-metastasized lung cancer.
    1. Neuroscience

    Hippocampal replay of experience at real-world speeds

    Eric L Denovellis et al.
    A new state space decoder revealed that most hippocampal sharp-wave ripples contain coherent spatial content, and that this 'replay' typically progresses at speeds similar to those seen during actual experiences.
    1. Medicine
    2. Stem Cells and Regenerative Medicine

    Adult stem cell-derived complete lung organoid models emulate lung disease in COVID-19

    Courtney Tindle et al.
    An integrated stem cell-based disease modeling and computational approach demonstrates how proximal airway epithelium is critical for SARS-CoV-2 infectivity and distal alveolar cells are critical for simulating the host responses.
    1. Neuroscience

    Coherent theta activity in the medial and orbital frontal cortices encodes reward value

    Linda M Amarante, Mark Laubach
    The more you want it or the better it is, the stronger is medial frontal theta (paraphrased from a retweet of the preprint by Dr James Hyman).
    1. Evolutionary Biology
    2. Genetics and Genomics

    The whale shark genome reveals patterns of vertebrate gene family evolution

    Milton Tan et al.
    The new whale shark genome assembly represents the best gapless chondrichthyan genome assembly yet, and comparative genomic analyses provide insights into the evolution of vertebrate genome origins, immunity, and gigantism.
    1. Neuroscience

    Coupling between motor cortex and striatum increases during sleep over long-term skill learning

    Stefan M Lemke et al.
    Sleep spindles, distinctive brain activity patterns occurring in non-REM sleep, modify cross-area connectivity in the motor network relevant for behavioral flexibility, impacting subsequent behavior.
    1. Cell Biology
    2. Immunology and Inflammation

    Endothelial junctional membrane protrusions serve as hotspots for neutrophil transmigration

    Janine JG Arts et al.
    Neutrophils use dorsal membrane protrusions of endothelial cells to cross the vascular wall.

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