236 results found
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Selective activation of FZD7 promotes mesendodermal differentiation of human pluripotent stem cells

    Diana Gumber et al.
    Selective activation of FZD7 signaling with an engineered WNT mimetic promotes early developmental programs, including endodermal lineage specification, in human pluripotent stem cells.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    The Crohn’s disease polymorphism, ATG16L1 T300A, alters the gut microbiota and enhances the local Th1/Th17 response

    Sydney Lavoie et al.
    Gnotobiotic and conventional mouse models of the IBD ATG16L1T300A SNP reveal gene-microbiota-immune interactions.
    1. Evolutionary Biology

    High potency of sequential therapy with only β-lactam antibiotics

    Aditi Batra et al.
    Sequential therapy with only β-lactam antibiotics achieves surprisingly high potency by exploiting both low rates of spontaneous resistance emergence and low rates of spontaneous cross-resistance among the drugs in sequence.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Post-translational regulation of retinal IMPDH1 in vivo to adjust GTP synthesis to illumination conditions

    Anna Plana-Bonamaisó et al.
    The nucleotide sensing ability of IMPDH1 at the Bateman domain is regulated by light-dependent phosphorylation in the retina, to adjust GTP synthesis to illumination conditions.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    A widely distributed metalloenzyme class enables gut microbial metabolism of host- and diet-derived catechols

    Vayu Maini Rekdal et al.
    A previously unrecognized group of metalloenzymes enables human gut microbes to metabolize dietary molecules and neurotransmitters and likely mediates interactions and metabolism among environmental microorganisms.
    1. Ecology

    Global warming reduces leaf-out and flowering synchrony among individuals

    Constantin M Zohner et al.
    Individuals differ in how their leaf-out and flowering are regulated by abiotic stimuli and, under climate warming, this leads to reduced within-population phenological synchrony, impacting mutualistic and antagonistic community interactions.
    1. Structural Biology and Molecular Biophysics

    Cryo-EM structure of respiratory complex I at work

    Kristian Parey et al.
    The site of ubiquinone binding observed in the cryo-EM structure of respiratory complex I during turnover supports a two-state stabilization change mechanism.
    1. Epidemiology and Global Health
    2. Medicine

    A high rate of COVID-19 vaccine hesitancy in a large-scale survey on Arabs

    Eyad A Qunaibi et al.
    Providing important data regarding the proportion of COVID-19 vaccine hesitancy and barriers toward vaccination in Arabic-speaking people to guide addressing the problem and achievement of widespread vaccination and collective immunity.
  1. Annual report: Looking back on 2017

    A reflection on eLife's achievements in 2017, notably in convening and supporting communities, modernising technology for research communication and partnering with early-career researchers.
  2. Webinar invitation: #ECRWednesday series for early-stage researchers

    eLife hosts a programme of monthly webinars for early-career researchers in life science and biomedicine as a platform to share opportunities and explore issues around building a successful research career.

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