The structure of gp41with its membrane anchors highlights the flexible linkage of the transmembrane regions and the fuson peptides, which generates an asymmetric conformation, a potential target of MPER bNAbs.

BCR profiling of tumor infiltrating B cells alongside with circulating and lymph node-resident B cells deepens understanding of their unique properties.

Nonlinear receptive field subunits in retinal ganglion cells are isolated and characterized by clustering spike-triggered stimuli, and validated on population responses to naturalistic and novel closed loop stimuli.

The most influential clocks within the Drosophila circadian clock neuron network form the fewest synapses within the network, and neurons that do not themselves contain molecular clocks mediate connections between those that do, suggesting a key role in timekeeping.

Endogenous laminins are necessary to build a functional acinus via generating NO, activating p53, HOXD10 and other positive players, but tumor cells neither make laminin nor generate NO, unless they are reverted to an organized structure.

The identification of a neural circuit that drives a specific grooming movement in Drosophila reveals that it may also control movement parameters, such as duration.

The mechanism of substrate binding cooperativity in human thymidylate synthase does not derive from millisecond dynamic interconversion between active and inactive conformations in solution, but instead results primarily from differential changes in faster side-chain motions (conformational entropy), facilitated by a disordered N-terminus.

Puzzle-shape cells in the epidermis of many plants form due to a development constraint based on mechanical forces.

By integrating theoretical and empirical approaches, the results show that linking abiotic factor and biotic interactions on the niche width will be critical for understanding species-specific responses to climate change.