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    1. Cell Biology

    Macrophage inflammation resolution requires CPEB4-directed offsetting of mRNA degradation

    Clara Suñer, Annarita Sibilio ... Raúl Méndez
    Decay rate of mRNAs encoding inflammatory regulators is controlled by the balance between AU-rich element-mediated deadenylation and cytoplasmic polyadenylation element-mediated polyadenylation.
    1. Developmental Biology
    2. Neuroscience

    Differentiation signals from glia are fine-tuned to set neuronal numbers during development

    Anadika R Prasad, Inês Lago-Baldaia ... Vilaiwan M Fernandes
    Extrinsic signals establish an invariant and stereotyped pattern of neuronal differentiation and programmed cell death in the Drosophila visual system.
    1. Biochemistry and Chemical Biology

    Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis

    Martin Steger, Federico Diez ... Matthias Mann
    Parkinson's kinase LRRK2 phosphorylates a distinct subset of Rabs, and LRRK2-dependent phosphorylation links LRKK2 to ciliogenesis.
    1. Cell Biology
    2. Immunology and Inflammation

    HLJ1 amplifies endotoxin-induced sepsis severity by promoting IL-12 heterodimerization in macrophages

    Wei-Jia Luo, Sung-Liang Yu ... Kang-Yi Su
    Single-cell RNA sequencing reveals HLJ1 as a novel immunomodulator for multicellular pathway of macrophages and NK cells, contributing to organ injury and sepsis death through amplified IL-12/IFN-γ axis.
    1. Neuroscience

    An event map of memory space in the hippocampus

    Lorena Deuker, Jacob LS Bellmund ... Christian F Doeller
    Evidence suggests a common coding mechanism underlies spatial and temporal aspects of episodic memory in the human hippocampus.
    1. Neuroscience

    A role for descending auditory cortical projections in songbird vocal learning

    Yael Mandelblat-Cerf, Liora Las ... Michale S Fee
    Midbrain dopaminergic neurons and a cortex-like structure called the arcopallium form part of a circuit that enables young songbirds to compare their own song with a template stored in memory, and use any discrepancies to improve their performance.
    1. Developmental Biology
    2. Genetics and Genomics

    Feedback between a retinoid-related nuclear receptor and the let-7 microRNAs controls the pace and number of molting cycles in C. elegans

    Ruhi Patel, Himani Galagali ... Alison R Frand
    A genetic oscillator composed of NHR-23 and let-7 family of microRNAs links the molting cycle timer and the heterochronic pathway to regulate the pace of molting in C. elegans and ensure that worms molt only four times.
    1. Cell Biology
    2. Immunology and Inflammation

    Succinate mediates inflammation-induced adrenocortical dysfunction

    Ivona Mateska, Anke Witt ... Vasileia Ismini Alexaki
    Inflammation reprograms the citrate cycle in adrenocortical cells leading to altered steroidogenesis.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Molecular mechanism for direct actin force-sensing by α-catenin

    Lin Mei, Santiago Espinosa de los Reyes ... Gregory M Alushin
    Biophysical and structural studies reveal how low piconewton forces across actin enhance binding by the critical cell-cell adhesion protein α-catenin versus its force insensitive homolog vinculin.
    1. Immunology and Inflammation

    IRAK1-dependent Regnase-1-14-3-3 complex formation controls Regnase-1-mediated mRNA decay

    Kotaro Akaki, Kosuke Ogata ... Osamu Takeuchi
    Regnase-1, an RNase suppressing proinflammatory mRNAs, interacts with 14-3-3, which diminishes cytokine mRNA recognition and the nuclear-cytoplasmic shuttling of Regnase-1 under inflammatory conditions.