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    1. Developmental Biology

    Dkk2 promotes neural crest specification by activating Wnt/β-catenin signaling in a GSK3β independent manner

    Arun Devotta et al.
    Dkk2, a member of the Dikkopf family of Wnt antagonists, acts as a positive regulator of Wnt signaling during neural crest formation.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Wnt- and glutamate-receptors orchestrate stem cell dynamics and asymmetric cell division

    Sergi Junyent et al.
    Receptors for two distinct pathways are linked to choreograph the dynamic interaction of Wnt on the stem cell membrane, which leads to the control of asymmetric cell division.
    1. Physics of Living Systems

    Measuring ligand-cell surface receptor affinities with axial line-scanning fluorescence correlation spectroscopy

    Antonia Franziska Eckert et al.
    A robust fluorescence microscopy-based data acquisition and analysis framework affords the precise measurement of cell surface receptor affinities toward their cognate ligands and their densities in live cells/tissues.
    1. Biochemistry and Chemical Biology
    2. Developmental Biology

    Tailored tetravalent antibodies potently and specifically activate Wnt/Frizzled pathways in cells, organoids and mice

    Yuyong Tao et al.
    Modular tetravalent antibodies can be engineered to stimulate signaling through any combination of Frizzled and LRP receptors to drive organoid growth and mobilize endogenous stem cells in vivo.
    1. Cancer Biology

    Sam68/KHDRBS1 is critical for colon tumorigenesis by regulating genotoxic stress-induced NF-κB activation

    Kai Fu et al.
    The nuclear protein Sam68 plays a role in the genotoxic stress-initiated "nuclear to cytoplasmic" activation of NF-κB and is involved in the development and survival of colon cancer.
    1. Developmental Biology
    2. Cell Biology

    Wnt/PCP controls spreading of Wnt/β-catenin signals by cytonemes in vertebrates

    Benjamin Mattes et al.
    Wnt signaling regulates its effective signaling range by controlling Wnt ligand transport on signaling filopodia within vertebrate tissues.
    1. Cell Biology

    A MET-PTPRK kinase-phosphatase rheostat controls ZNRF3 and Wnt signaling

    Minseong Kim et al.
    HGF-MET signaling phosphorylates- and PTPRK dephosphorylates ZNRF3 to regulate ZNRF3 internalization, functioning as a rheostat for Wnt signaling.
    1. Structural Biology and Molecular Biophysics
    2. Developmental Biology

    Structure and functional properties of Norrin mimic Wnt for signalling with Frizzled4, Lrp5/6, and proteoglycan

    Tao-Hsin Chang et al.
    The crystal structure of Norrie Disease Protein in complex with the extracellular cysteine-rich domain of Frizzled4 receptor and sucrose octasulfate reveals binding sites for Frizzled4, low density lipoprotein receptor related protein 5/6, and proteoglycan.
    1. Cell Biology
    2. Neuroscience

    The amyloid precursor protein is a conserved Wnt receptor

    Tengyuan Liu et al.
    The amyloid precursor protein known for its role in causing familial Alzheimer's disease directly interacts with secreted proteins, called Wnts, known for their key roles in brain development and homeostasis, suggesting the two processes may be directly linked.