LSD induces a pattern of changed global brain connectivity characterized by hypo-connectivity in associative areas and hyper-connectivity across sensory and somatomotor areas that is dependent on the serotonin 2A receptor.

Lysine-specific demethylase 1 (Lsd1) has an essential role during both the early and later stages of blood cell development.

Within the isolated lid sub-complex of the proteasome, a finely tuned network of interactions maintains the deubiquitinase in an inhibited conformation; dramatic rearrangements of the lid subunits upon incorporation into the holoenzyme lead to the deubiquitinase’s activation.

The maternally provided histone demethylase LSD1/KDM1A has an instrumental role at the beginning of life, shaping the histone methylation landscape and the transcriptional repertoire of the early mouse embryo.

Lysine-specific demethylase-1 acts as an epigenetic barrier against glucocorticoid-induced atrophy and exercise-induced hypertrophy in skeletal muscle.

Mammalian Dscams require different intracellular interactions in different cell types during neural circuit formation to promote self-avoidance.

Building on previous work (Felch et al., 2016), it is shown that inverse effectiveness, a central property of multisensory integration, in the optic tectum is mediated by the activation of NMDA-type glutamate receptors, resulting in a response greater than the sum of responses to each individual sensory modality.

Pupil-linked arousal dynamics are influenced more strongly by high-level internal belief states than by low-level sensory events during decision-making.

Computational models of large-scale cortical dynamics, integrating gene expression mapping to pattern pharmacological modulation across cortex, capture inter-areal topographies of functional connectivity alterations induced by lysergic acid diethylamide, providing a framework for simulating effects of pharmacology in the human brain.

Functional magnetic resonance imaging performed while people imagined directions from stationary viewpoints supports theories suggesting that spatially tuned cells such as grid cells underlie mental simulation for future thinking.