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    1. Developmental Biology
    2. Neuroscience

    Differential spatiotemporal development of Purkinje cell populations and cerebellum-dependent sensorimotor behaviors

    Gerrit Cornelis Beekhof et al.
    Different Purkinje cell subpopulations show distinct developmental profiles of physiological activity, climbing fiber inputs and axonal and dendritic morphology, matching different timelines of cerebellum-dependent behaviors.
    1. Cancer Biology
    2. Cell Biology

    KSR1- and ERK-dependent translational regulation of the epithelial-to-mesenchymal transition

    Chaitra Rao et al.
    A key Ras-driven signaling pathway stimulates the preferential translation of an effector, EPSTI1, that is both necessary and sufficient for the epithelial-to-mesenchymal transition-like phenotype in colorectal cancer cells.
    1. Cell Biology

    An in vivo reporter for tracking lipid droplet dynamics in transparent zebrafish

    Dianne Lumaquin et al.
    A novel transgenic lipid droplet reporter in transparent casper zebrafish allows direct visualization of individual lipid droplets in a living animal.
    1. Cell Biology

    Micron-scale geometrical features of microtubules as regulators of microtubule organization

    Nandini Mani et al.
    Micron-scale geometrical features of individual microtubule polymers and polymer networks encode information that guides the self-organization of microtubules into specialized structures for diverse cellular functions such as cell division and signaling in eukaryotic cells.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Detecting adaptive introgression in human evolution using convolutional neural networks

    Graham Gower et al.
    Convolutional neural networks are an effective tool for detecting archaic adaptive introgression from genomic data.
    1. Microbiology and Infectious Disease

    Genetic code expansion enables visualization of Salmonella type three secretion system components and secreted effectors

    Moirangthem Kiran Singh et al.
    Genetic code expansion (GCE) enables site-specific labeling and visualization of Salmonella secreted effectors, secretion system components and provides a viable alternative for labeling proteins that do not tolerate N- or C-terminal tags.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Asymmetric localization of the cell division machinery during Bacillus subtilis sporulation

    Kanika Khanna et al.
    During sporulation, FtsAZ filaments mediating cell division in Bacillus subtilis are positioned asymmetrically around the septum only on the mother cell side, making the septum thinner than during vegetative growth.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Bacterial death and TRADD-N domains help define novel apoptosis and immunity mechanisms shared by prokaryotes and metazoans

    Gurmeet Kaur et al.
    Prokaryotic TRADD-N and Death-like adaptor domains in diverse predicted apoptosis and immune systems from multicellular prokaryotes and metazoans indicate the common origin of key apoptosis mechanisms required for the stabilization of multicellularity.
    1. Neuroscience

    Presynaptic NMDA receptors facilitate short-term plasticity and BDNF release at hippocampal mossy fiber synapses

    Pablo J Lituma et al.
    By facilitating glutamate and BDNF release, presynaptic NMDA receptors may control information transfer from the dentate gyrus to the CA3 area of the hippocampus.
    1. Neuroscience

    Corticothalamic gating of population auditory thalamocortical transmission in mouse

    Baher A Ibrahim et al.
    Sensory stimulation produces stochastic population responses in the cortex that are governed by layer 6 cortico-reticular projections that modulate thalamic synchrony.