Comparing the relative similarity of cellular molecules to alternate templates allows classification of related complexes in the cell using fewer particles than needed for 3D classification and is more practicable for low abundance complexes.

Investigation of dynamic gene regulation across cell types and environments reveals new GxE regulatory loci that are important for disease.

During ES cell differentiation, Yap1 directly regulates apoptosis-related genes like Bcl-2 and Mcl-1 to attenuate apoptosis and promote cell survival to allow for successful cell fate changes.

Caffeine modulates the genetic risk for cardiovascular disease through changes in target gene expression, likely due to regulation of transcription factor binding.

2D template matching enables a streamlined single-particle cryogenic electron microscopy workflow that can be used to discover new high-resolution structural features in molecules and complexes, such as bound ligands and drugs.

The excessive behavioral variability associated with adolescence is the result of greater instability of widespread or global gain signals which produces greater variability in the amplitude of expression of whole-brain states of task-related activity.

T3 is taken up by axonal termini and is retrogradely transported into endosomal vesicles to the cell nucleus, where it regulates gene expression.

Cognitive performance is supported by symbiotic metabolic and neuro-vascular responses in task-specific brain networks.

Direct in-vivo measurements in the human brain test validity of detailed computational models of trancranial electric stimulation and show that electric fields in the brain are weaker than currently assumed.

2D template matching complements 3D template matching of tomograms, providing fast and specific detection of molecules in cryo-EM images of cells, as well as generating 3D reconstructions from detected targets.