46 results found
    1. Stem Cells and Regenerative Medicine

    Adult zebrafish Langerhans cells arise from hematopoietic stem/progenitor cells

    Sicong He et al.
    Adult zebrafish Langerhans cells are derived from hematopoietic stem/progenitor cells but not Erythro-myeloid progenitors.
    1. Developmental Biology

    Zebrafish macrophage developmental arrest underlies depletion of microglia and reveals Csf1r-independent metaphocytes

    Laura E Kuil et al.
    Embryonic and definitive macrophages require colony-stimulating factor 1 receptor, whereas non-hematopoietic metaphocytes that resemble macrophages do not, explaining the relative high numbers of putative macrophages in Csf1r-deficient zebrafish.
    1. Neuroscience

    Mechanotransduction: Two views of the same stimulus

    Wayne A Johnson
    Signals from two different membrane proteins are combined to modulate how strongly sensory neurons respond to mechanical force.
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    1. Human Biology and Medicine

    Diabetes: Partners for life

    Lena Eliasson, Anna Wendt
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    1. Cell Biology
    2. Developmental Biology

    Macrophages are necessary for epimorphic regeneration in African spiny mice

    Jennifer Simkin et al.
    Inflammatory cells differentially regulate a scarring versus a regenerating response to injury in mammals.
    1. Immunology and Inflammation

    CD301b+ dendritic cells suppress T follicular helper cells and antibody responses to protein antigens

    Yosuke Kumamoto et al.
    CD301b dendritic cells potently suppress antibody responses by limiting the activity of follicular helper T cells and germinal center B cells.
    1. Immunology and Inflammation

    Dithranol targets keratinocytes, their crosstalk with neutrophils and inhibits the IL-36 inflammatory loop in psoriasis

    Theresa Benezeder et al.
    Targeting the differentiation regulators and/or AMPs of keratinocytes, rather than targeting immune cells, may be an alternative approach for topical anti-psoriatic treatment, an area with high need for new drugs.
    1. Developmental Biology

    Upregulation of neurovascular communication through filamin abrogation promotes ectopic periventricular neurogenesis

    Shauna L Houlihan et al.
    Analyses based on the mouse model of a human genetic disease reveal that the neuron production of cerebral tissue can be boosted by escalated signaling between neural progenitors and the vasculature.
    1. Cell Biology

    Adiponectin is essential for lipid homeostasis and survival under insulin deficiency and promotes β-cell regeneration

    Risheng Ye et al.
    Under insulinopenic conditions, the hormone adiponectin is essential for lipid uptake specifically in subcutaneous white adipose tissue, and is sufficient to ameliorate islet lipotoxicity.

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