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    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    The interplay of RNA:DNA hybrid structure and G-quadruplexes determines the outcome of R-loop-replisome collisions

    Charanya Kumar, Sahil Batra ... Dirk Remus
    Reconstitution of orientation-specific R-loop-replisome collisions with purified proteins reveals the differential impact of R-loop-associated RNA:DNA hybrids and G-quadruplexes on replication fork progression.
    1. Cell Biology

    N-WASP-dependent branched actin polymerization attenuates B-cell receptor signaling by increasing the molecular density of receptor clusters

    Anshuman Bhanja, Margaret K Seeley-Fallen ... Wenxia Song
    B-cells generate inner actomyosin foci from lamellipodial actin networks to drive cell contraction on antigen-presenting surfaces, which causes signaling molecule disassociation from B-cell receptor clusters and signal attenuation.
    1. Developmental Biology
    2. Neuroscience

    Dentate gyrus development requires a cortical hem-derived astrocytic scaffold

    Alessia Caramello, Christophe Galichet ... Robin Lovell-Badge
    An astrocytic scaffold that depends on SOX9 guides embryonic neuronal progenitors toward the developing dentate gyrus.
    1. Physics of Living Systems

    Spatial control of neuronal metabolism through glucose-mediated mitochondrial transport regulation

    Anamika Agrawal, Gulcin Pekkurnaz, Elena F Koslover
    A quantitative analysis of glucose-dependent transport regulation indicates that mitochondrial accumulation in regions of high nutrient availability can enhance metabolism in neuronal axons under physiologically relevant conditions.
    1. Cell Biology

    A fat-2(wa17) suppressor screen in C. elegans reveals genetic adaptations to polyunsaturated fatty acid deficiency

    Delaney Kaper, Uroš Radović ... Marc Pilon
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Solid
    1. Microbiology and Infectious Disease

    Lacticaseibacillus rhamnosus P118 enhances host tolerance to Salmonella infection by promoting microbe-derived indole metabolites

    Baikui Wang, Xianqi Peng ... Min Yue
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Compelling
    1. Medicine
    2. Neuroscience

    Dual-modal metabolic analysis reveals hypothermia-reversible uncoupling of oxidative phosphorylation in neonatal brain hypoxia-ischemia

    Naidi Sun, Yu-Yo Sun ... Song Hu
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Neuroscience

    Astrocytes gate long-term potentiation in hippocampal interneurons

    Weida Shen, Yejiao Tang ... Ling-Hui Zeng
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Immunology and Inflammation

    Cytosolic S100A8/A9 promotes Ca2+ supply at LFA-1 adhesion clusters during neutrophil recruitment

    Matteo Napoli, Roland Immler ... Monika Pruenster
    Cytosolic S100A8/A9 enhances Ca2+ availability at LFA-1 adhesion sites, facilitating neutrophil recruitment and extravasation by supporting proper integrin signaling and cytoskeletal rearrangement.
    1. Stem Cells and Regenerative Medicine

    The mini-IDLE 3D biomimetic culture assay enables interrogation of mechanisms governing muscle stem cell quiescence and niche repopulation

    Erik Jacques, Yinni Kuang ... Penney M Gilbert
    A user-friendly, and modular, 3D skeletal muscle culture assay enables iterative studies of murine muscle stem cell pool size regulation, functional heterogeneity, return to quiescence, and age-associated functional defects within a 96-well footprint.
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