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    1. Computational and Systems Biology
    2. Developmental Biology

    Elastic force restricts growth of the murine utricle

    Ksenia Gnedeva et al.
    Computational modeling and molecular-biological analysis reveal the role of mechanical force and downstream Yap signaling in growth control during the development and regeneration of sensory epithelium of the inner ear.
    1. Physics of Living Systems

    Spatial control of neuronal metabolism through glucose-mediated mitochondrial transport regulation

    Anamika Agrawal et al.
    A quantitative analysis of glucose-dependent transport regulation indicates that mitochondrial accumulation in regions of high nutrient availability can enhance metabolism in neuronal axons under physiologically relevant conditions.
    1. Neuroscience

    Model-based fMRI reveals dissimilarity processes underlying base rate neglect

    Sean R O'Bryan et al.
    Model-based imaging shows that the rostrolateral prefrontal cortex supports dissimilarity-based heuristics that people may use when they are confronted with ambiguous scenarios.
    1. Physics of Living Systems

    Rheotaxis facilitates upstream navigation of mammalian sperm cells

    Vasily Kantsler et al.
    Mammalian sperm subject to shear flow swim in upstream spirals along the walls bounding such flows, thereby demonstrating a robust mechanism for upstream navigation to the ovum.
    1. Neuroscience

    A spatial memory signal shows that the parietal cortex has access to a craniotopic representation of space

    Mulugeta Semework et al.
    Neural recordings and analyses illustrate a unique lateral intraparietal area (LIP) response that may contribute to how primates can establish a memory of the environment in a useful coordinate frame, and maintain this representation of the environment over time.
    1. Structural Biology and Molecular Biophysics

    Piezo’s membrane footprint and its contribution to mechanosensitivity

    Christoph A Haselwandter, Roderick MacKinnon
    Membrane mechanics predict that the ion channel Piezo recruits the surrounding membrane to amplify its sensitivity to changes in membrane tension, with greatest sensitivity in the low-tension regime.
    1. Physics of Living Systems

    Measuring ligand-cell surface receptor affinities with axial line-scanning fluorescence correlation spectroscopy

    Antonia Franziska Eckert et al.
    A robust fluorescence microscopy-based data acquisition and analysis framework affords the precise measurement of cell surface receptor affinities toward their cognate ligands and their densities in live cells/tissues.
    1. Developmental Biology
    2. Physics of Living Systems

    Nuclear crowding and nonlinear diffusion during interkinetic nuclear migration in the zebrafish retina

    Afnan Azizi et al.
    The evolving spatial distribution of nuclei between apical and basal surfaces of the developing retinal neuroepithelium is quantitatively described by a nonlinear diffusion equation accounting for crowding within the tissue.
    1. Physics of Living Systems

    Stochastic bond dynamics facilitates alignment of malaria parasite at erythrocyte membrane upon invasion

    Sebastian Hillringhaus et al.
    The bond-based adhesion model is a key step toward a realistic description of RBC-parasite interaction, which allows the investigation of more realistic scenarios and is relevant for other biological systems.
    1. Neuroscience

    An event map of memory space in the hippocampus

    Lorena Deuker et al.
    Evidence suggests a common coding mechanism underlies spatial and temporal aspects of episodic memory in the human hippocampus.