40 results found
    1. Microbiology and Infectious Disease

    Population structuring of multi-copy, antigen-encoding genes in Plasmodium falciparum

    Yael Artzy-Randrup et al.
    Mathematical modeling shows that local populations of the malaria parasite self-organize into a limited number of transient but distinct strains through competition for hosts in immunity space.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Hypothemycin, a fungal natural product, identifies therapeutic targets in Trypanosoma brucei

    Mari Nishino et al.
    Hypothemycin, which inhibits a number of protein kinases, kills the T. brucei parasites that cause sleeping sickness and reveals new therapeutic targets for the disorder.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Mechanism of chiral proofreading during translation of the genetic code

    Sadeem Ahmad et al.
    Structural biology has elucidated the mechanism of a configuration-specific enzyme that decouples D-amino acids from the translational machinery and, therefore, is involved in the enforcement of homochirality during protein synthesis.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Modes of flagellar assembly in Chlamydomonas reinhardtii and Trypanosoma brucei

    Johanna L Höög et al.
    Comparative electron tomography of growing flagellar tips reveals that axonemal growth differs between short and long flagella, and between species.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Single-molecule analysis reveals self assembly and nanoscale segregation of two distinct cavin subcomplexes on caveolae

    Yann Gambin et al.
    New insights into the assembly and membrane interactions of the caveolar coat complex reveal the reversible association/dissociation of distinct subcomplexes onto the membrane, which differs from the assembly/disassembly of clathrin-coated pits.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structure of the SAS-6 cartwheel hub from Leishmania major

    Mark van Breugel et al.
    The X-ray structure of the SAS-6 cartwheel hub from Leishmania major demonstrates that SAS-6 can be sufficient to determine centriolar cartwheel symmetry.
    1. Cell Biology

    Flagellar Growth: Boarder control on the IFT train

    Cécile Fort, Philippe Bastin
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    1. Cell Biology

    The GTPase IFT27 is involved in both anterograde and retrograde intraflagellar transport

    Diego Huet et al.
    A small GTPase within the flagellum can participate in the control of transport from the base to the tip of the flagellum, and back again.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Global distribution maps of the leishmaniases

    David M Pigott et al.
    Maps defining environmental risk of the leishmaniases provide insights into the ecology of these diseases and identify regions to target public health measures and inform future burden estimates.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    The homo-oligomerisation of both Sas-6 and Ana2 is required for efficient centriole assembly in flies

    Matthew A Cottee et al.
    The structure of the Ana2 Central Coiled-Coil Domain provides insight into how centriolar cartwheel components may be recruited and assembled, and indicates that cartwheel assembly involves more than just SAS-6 oligomerisation.

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