637 results found
    1. Microbiology and Infectious Disease

    Perinatal hormones favor CC17 group B Streptococcus intestinal translocation through M cells and hypervirulence in neonates

    Constantin Hays et al.
    Hormonal concentrations found in over 7-day-old neonates favor CC17 GBS invasiveness in a process linked to intestinal M cells maturation and mediated by the CC17 GBS surface protein Srr2.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Profilin and formin constitute a pacemaker system for robust actin filament growth

    Johanna Funk et al.
    Profilin release from the filament end controls the speed of actin growth at physiological conditions.
    1. Cell Biology

    Negative regulation of autophagy by UBA6-BIRC6–mediated ubiquitination of LC3

    Rui Jia, Juan S Bonifacino
    An ensemble of the ubiquitin-activating enzyme UBA6 and ubiquitin-conjugating enzyme/ubiquitin-ligase BIRC6 mediates ubiquitination of LC3, targeting the latter for proteasomal degradation and thus attenuating autophagic degradation of cellular substrates.
    1. Developmental Biology

    Mask family proteins ANKHD1 and ANKRD17 regulate YAP nuclear import and stability

    Clara Sidor et al.
    The MASK family of proteins regulate the action of the YAP/TAZ family of transcriptional coactivators, key regulators of stem cell proliferation and cancer.
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    IFI16, a nuclear innate immune DNA sensor, mediates epigenetic silencing of herpesvirus genomes by its association with H3K9 methyltransferases SUV39H1 and GLP

    Arunava Roy et al.
    The innate immune DNA sensor IFI16 is in association with H3K9 methyltransferases SUV39H1 and GLP under physiological conditions in the nucleus which facilitates the epigenetic silencing of foreign viral DNA.
    1. Cell Biology

    The mammalian LINC complex component SUN1 regulates muscle regeneration by modulating drosha activity

    Tsui Han Loo et al.
    The LINC complex, that couples the interphase cytoskeleton to the nucleus, regulates the processing of a cluster of miRNAs required for muscle regeneration by recruiting and interacting directly with Drosha.
    1. Cell Biology
    2. Neuroscience

    Cocaine-induced endocannabinoid signaling mediated by sigma-1 receptors and extracellular vesicle secretion

    Yoki Nakamura et al.
    Non-synaptic extracellular vesicles may be involved in the release of endogenous cannabinoids in the central nervous system thereby representing a novel mechanism to mediate their effects on synaptic transmission.
    1. Plant Biology

    Dynamic ubiquitination determines transcriptional activity of the plant immune coactivator NPR1

    Michael J Skelly et al.
    Expression of plant immune genes is controlled by the opposing actions of ubiquitin ligases and deubiquitinases that modify the master coactivator NPR1, thereby regulating its intrinsic transcriptional activity.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Exploring structural dynamics of a membrane protein by combining bioorthogonal chemistry and cysteine mutagenesis

    Kanchan Gupta et al.
    A facile method is implemented to modify membrane proteins with biophysical reporters using cysteine-independent approaches in live cells.
    1. Immunology and Inflammation

    Inhibition of ErbB kinase signalling promotes resolution of neutrophilic inflammation

    Atiqur Rahman et al.
    Targeting ErbB receptor tyrosine kinases modifies neutrophil survival and inflammation across multiple species, and reveals a new use for ErbB therapeutics in resolving inflammatory disease.

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