Skip to Content
eLife home page
Submit my research
(via ORCID - An ORCID is a persistent digital identifier for researchers)
Browse the search results
Page 2 of 78
The fibronectin synergy site re-enforces cell adhesion and mediates a crosstalk between integrin classes
Maria Benito-Jardón et al.
The fibronectin synergy site is only required in vivo when forces exceed or αvβ3 integrin levels fall below certain thresholds.
Chromosomes and Gene Expression
Human Biology and Medicine
Mutations in L-type amino acid transporter-2 support
as a novel gene involved in age-related hearing loss
Meritxell Espino Guarch et al.
SLC7A8 a neutral amino acid transporter has a key role in the maintenance of hearing during aging and its absence causes early onset of hearing loss.
Computational and Systems Biology
Principles of cellular resource allocation revealed by condition-dependent proteome profiling
Eyal Metzl-Raz et al.
Steadily growing cells prepare for conditions that demand increased translation by producing excess ribosomes, at the expense of lower steady-state growth rate.
Immunology and Inflammation
IgM and IgD B cell receptors differentially respond to endogenous antigens and control B cell fate
Mark Noviski et al.
Self-reactive B cells downregulate the IgM but not the IgD B cell receptor, and this serves as a critical tolerance mechanism because IgD is less sensitive to bona fide endogenous antigens than IgM.
Biochemistry and Chemical Biology
O-GlcNAc on NOTCH1 EGF repeats regulates ligand-induced Notch signaling and vascular development in mammals
Shogo Sawaguchi et al.
The transfer of O-GlcNAc by EOGT to specific EGF repeats of NOTCH1 promotes DLL4 binding, Notch signaling, and retinal vascular development.
Heat stress promotes longevity in budding yeast by relaxing the confinement of age-promoting factors in the mother cell
Sandro Baldi et al.
To promote longevity under heat stress shares yeast aging factors with progeny through a down-regulation of the diffusion barrier in the membranes between the mitotic cells.
Revised roles of ISL1 in a hES cell-based model of human heart chamber specification
Roberto Quaranta et al.
Loss and gain-of-function investigation uncovers a regulatory network controlling human heart chamber specification in which the cardiac precursor gene ISL1 accelerates ventricular induction and antagonizes retinoic acid-driven atrial commitment.
Dynamic metabolic exchange governs a marine algal-bacterial interaction
Einat Segev et al.
Physical and chemical interactions with bacteria influence the life and death of
, a bloom-forming micro-alga important in global biogeochemical cycles.
Biochemistry and Chemical Biology
Structural Biology and Molecular Biophysics
Structural basis of transcription arrest by coliphage HK022 Nun in an
RNA polymerase elongation complex
Jin Young Kang et al.
Cryo-electron microscopy structures show how coliphage HK022 Nun blocks
RNA polymerase translocation by mediating multiple interactions between the RNA polymerase and nucleic acids.
Microbiology and Infectious Disease
parasites deploy RhopH2 into the host erythrocyte to obtain nutrients, grow and replicate
Natalie A Counihan et al.
Plasmodium parasites secrete RhopH2 from the rhoptry organelle into their host red blood cell to facilitate the uptake of essential nutrients required for parasite replication and survival.
Be the first to read new articles from eLife
Sign up for alerts
Please leave this field empty
Back to top