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    1. Developmental Biology

    Cell Fate Choice: Survival of the fattest

    Sophie M Morgani, Joshua M Brickman
    Version of Record
    Insight
    1. Developmental Biology

    Early patterning and specification of cardiac progenitors in gastrulating mesoderm

    W Patrick Devine, Joshua D Wythe ... Benoit G Bruneau
    Multipotent cardiac precursors within a population of mesoderm are rapidly fated to specific anatomic locations in the developing mouse heart.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Chromerid genomes reveal the evolutionary path from photosynthetic algae to obligate intracellular parasites

    Yong H Woo, Hifzur Ansari ... Arnab Pain
    Analysis of chromerid algal genomes reveals how apicomplexans have evolved from free-living algae into successful eukaryotic parasites via massive losses and re-inventing functional roles of genes.
    1. Developmental Biology

    Is it possible to reconstruct an accurate cell lineage using CRISPR recorders?

    Irepan Salvador-Martínez, Marco Grillo ... Maximilian J Telford
    Computer simulations reveal the potential and limitations of recently proposed CRISPR-based cell lineage recorders, and suggest how the recorders' design can be optimised to yield more accurate cell lineage trees.
    1. Computational and Systems Biology
    2. Developmental Biology

    A stochastic epigenetic switch controls the dynamics of T-cell lineage commitment

    Kenneth KH Ng, Mary A Yui ... Hao Yuan Kueh
    The timing and outcome of mammalian cell lineage decisions can be controlled by slow, stochastic events on individual regulatory gene loci.
    1. Cell Biology

    A δ-cell subpopulation with a pro-β-cell identity contributes to efficient age-independent recovery in a zebrafish model of diabetes

    Claudio Andrés Carril Pardo, Laura Massoz ... Isabelle Manfroid
    Most regenerated cells after β-cell damage in zebrafish are Insulin+ Somatostatin+ bihormonal cells that are functional and able to restore glucose control.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Mouse B2 SINE elements function as IFN-inducible enhancers

    Isabella Horton, Conor J Kelly ... Edward B Chuong
    An epigenomic analysis in mouse macrophages reveals that a highly abundant transposable element exhibits activity as an immune inducible regulatory element.
    1. Stem Cells and Regenerative Medicine

    A mex3 homolog is required for differentiation during planarian stem cell lineage development

    Shu Jun Zhu, Stephanie E Hallows ... Bret J Pearson
    The planarian mex3-1 gene is required for non-stem cell fates and suppresses a stem cell fate in differentiating cells.
    1. Evolutionary Biology
    2. Genetics and Genomics

    The whale shark genome reveals patterns of vertebrate gene family evolution

    Milton Tan, Anthony K Redmond ... Timothy Read
    The new whale shark genome assembly represents the best gapless chondrichthyan genome assembly yet, and comparative genomic analyses provide insights into the evolution of vertebrate genome origins, immunity, and gigantism.
    1. Developmental Biology

    Nkx2.5 marks angioblasts that contribute to hemogenic endothelium of the endocardium and dorsal aorta

    Lyad Zamir, Reena Singh ... Eldad Tzahor
    Live imaging coupled with cell lineage tracing in chick and mouse embryos reveal that the cardiac regulatory gene Nkx2.5 is also transiently expressed in early extra-cardiac hemogenic angioblasts that migrate to the heart, yolk sac and dorsal aorta.