Jennifer McKey, Dilara N Anbarci ... Blanche Capel
A detailed characterization of mouse ovary development using tissue clearing and 3D lightsheet imaging identifies ovary folding, specification of cortical and medullary domains, and ovary encapsulation as major hallmarks of ovary morphogenesis.
David W Eyre, Sheila F Lumley ... Timothy M Walker
Risk factors for SARS-CoV-2 infection in healthcare workers included caring for Covid-19 patients, Black or Asian ethnicity, and Covid-19-positive household contacts, whereas a bundle of PPE-related measures protected ICU staff.
A compact neural network can form various associative memories that are encoded in a distributed manner, where each neuron stores different components of the memory.
Sofie Louise Valk, Philipp Kanske ... Tania Singer
Training attention-mindfulness, emotion-motivational, and social cognitive skills over the course of 3 months alters brain functional and microstructural organization as a function of training content.
David S Lorberbaum, Andrea I Ramos ... Scott Barolo
The seemingly simple, constitutive response of the patched/Ptch1 gene to Hedgehog signaling is in fact regulated by large batteries of context-specific Hedgehog-responsive enhancers in both fly and mouse, allowing tissue-specific tuning of the Hedgehog pathway in animal development and evolution.
Aditya Mahadevan, Michael T Pearce, Daniel S Fisher
Evolution of multiple closely related strains with host-pathogen-like interactions but only one niche and no tradeoffs, can give rise to a spatiotemporally chaotic ecological state that continually diversifies even with generalist mutations that slow the evolution.
Dcp2 C-terminal domain cis-regulatory elements collaborating with specific activators control decapping enzyme targeting and activation by orchestrating sequential assembly of distinct decapping complexes.
