363 results found
    1. Immunology and Inflammation

    LMO2 is essential to maintain the ability of progenitors to differentiate into T-cell lineage in mice

    Ken-ichi Hirano, Hiroyuki Hosokawa ... Katsuto Hozumi
    LMO2 plays an important role in the maintenance of T lymphocyte competence and survival of pre-thymic progenitors by regulating the expression of Bcl11a and Tcf7 genes.
    1. Developmental Biology
    2. Neuroscience

    Area-specific development of distinct projection neuron subclasses is regulated by postnatal epigenetic modifications

    Kawssar Harb, Elia Magrinelli ... Christian Alfano
    Lmo4 specifies two neuron subclasses in the mouse neocortex by promoting postnatal co-expression of the transcription factors Ctip2 and Satb2 via chromatin remodelling in a time and area-specific manner.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    The LIM protein complex establishes a retinal circuitry of visual adaptation by regulating Pax6 α-enhancer activity

    Yeha Kim, Soyeon Lim ... Jin Woo Kim
    Regulation of Pax6 expression through the α-enhancer fine-tunes amacrine cell subtype number, and consequently, the visual output of the retina.
    1. Developmental Biology
    2. Neuroscience

    Genetic mechanisms control the linear scaling between related cortical primary and higher order sensory areas

    Andreas Zembrzycki, Adam M Stocker ... Dennis DM O'Leary
    Primary and higher order visual area dimensions in the neocortex are determined by the same genetic mechanisms during development which in turn also control the proportionate scaling between them.
    1. Stem Cells and Regenerative Medicine

    Single-cell transcriptomics reveals a new dynamical function of transcription factors during embryonic hematopoiesis

    Isabelle Bergiers, Tallulah Andrews ... Christophe Lancrin
    Single-cell transcriptomics analysis identifies the dynamic activity of transcription factors at the onset of hematopoeitic stem and progenitor cells formation during embryonic development.
    1. Developmental Biology
    2. Neuroscience

    Pum2 and TDP-43 refine area-specific cytoarchitecture post-mitotically and modulate translation of Sox5, Bcl11b, and Rorb mRNAs in developing mouse neocortex

    Kawssar Harb, Melanie Richter ... Kent Duncan
    RNA-binding proteins use both translational activation and repression of key molecular determinants to post-mitotically sculpt the identity and connectivity of developing mouse neocortex in an area-specific manner.
    1. Evolutionary Biology

    The structure of species discrimination signals across a primate radiation

    Sandra Winters, William L Allen, James P Higham
    Machine learning and experimental tests of receiver bias identify signal components critical to correct species classification in guenons, linking face pattern diversity to selection for species discrimination.
    1. Cell Biology
    2. Neuroscience

    PDZD7-MYO7A complex identified in enriched stereocilia membranes

    Clive P Morgan, Jocelyn F Krey ... Peter G Barr-Gillespie
    A new purification method for stereocilia membranes enables efficient immunoaffinity purification of rare protein complexes from hair cell stereocilia, including the newly described complex of deafness genes PDZD7 and MYO7A.
    1. Cell Biology

    Atg9 antagonizes TOR signaling to regulate intestinal cell growth and epithelial homeostasis in Drosophila

    Jung-Kun Wen, Yi-Ting Wang ... Guang-Chao Chen
    Atg9 inhibits TOR signaling to regulate cell growth and tissue homeostasis in Drosophila adult midgut.
    1. Cancer Biology

    Convergent organization of aberrant MYB complex controls oncogenic gene expression in acute myeloid leukemia

    Sumiko Takao, Lauren Forbes ... Alex Kentsis
    Definition of leukemia gene expression mechanisms reveals general principles of cancer gene control and offers a pharmacologic strategy for its therapeutic reprogramming.

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