LMO2 plays an important role in the maintenance of T lymphocyte competence and survival of pre-thymic progenitors by regulating the expression of Bcl11a and Tcf7 genes.
Kawssar Harb, Elia Magrinelli ... Christian Alfano
Lmo4 specifies two neuron subclasses in the mouse neocortex by promoting postnatal co-expression of the transcription factors Ctip2 and Satb2 via chromatin remodelling in a time and area-specific manner.
Andreas Zembrzycki, Adam M Stocker ... Dennis DM O'Leary
Primary and higher order visual area dimensions in the neocortex are determined by the same genetic mechanisms during development which in turn also control the proportionate scaling between them.
Single-cell transcriptomics analysis identifies the dynamic activity of transcription factors at the onset of hematopoeitic stem and progenitor cells formation during embryonic development.
RNA-binding proteins use both translational activation and repression of key molecular determinants to post-mitotically sculpt the identity and connectivity of developing mouse neocortex in an area-specific manner.
Machine learning and experimental tests of receiver bias identify signal components critical to correct species classification in guenons, linking face pattern diversity to selection for species discrimination.
Clive P Morgan, Jocelyn F Krey ... Peter G Barr-Gillespie
A new purification method for stereocilia membranes enables efficient immunoaffinity purification of rare protein complexes from hair cell stereocilia, including the newly described complex of deafness genes PDZD7 and MYO7A.
Definition of leukemia gene expression mechanisms reveals general principles of cancer gene control and offers a pharmacologic strategy for its therapeutic reprogramming.