Behavioral and molecular mechanistic studies elaborate the important role of ErbB4 in noradrenergic neurons associated with mania pathogenesis.

The long-term retention of extinction is enhanced by ontogenetic stimulation of locus coeruleus neurons applied during extinction of a reward-seeking response, further implicating noradrenaline in appetitive extinction.

Locus coeruleus responses to salient environmental stimuli drive increases in hippocampal dopamine that are important for long-term memory formation during trace fear conditioning.

Interrogating mouse locus coeruleus via large-scale multipatch whole-cell recordings uncovers its cellular heterogeneity and cell-type-specific wiring logic.

The overactivation of noradrenergic inputs to the amygdala during severe fear learning increases memory stability at the expense of lability, rendering the trace resistant to memory destabilization and reconsolidation.

A brain-wide neuromodulatory system enables rapid cortical plasticity to occur by signaling sensorimotor prediction errors across wide regions of the cerebral cortex.

Pupil diameter cannot accurately predict spiking activity in the locus coeruleus on a moment-by-moment basis, and exhibited large fluctuations to identical stimulation in the LC.

By combining ultra-high-field imaging with physiological and saliva measures it is established that interactions between locus coeruleus, hippocampus and amygdala vary along emotional memory stages, putatively reflecting distinct cognitive states.

Mice can learn to press a lever persistently for activation of a dopaminergic projection from the locus coeruleus to the hippocampal dentate gyrus.

Rapid increases in the brain’s level of alertness, or arousal, contribute to variability in decision making by reducing existing biases.