Impairment of the autocrine S1PR1-Gi signaling on HEVs results in high-endothelial cell apoptosis, reduced CCL21-secretion from HEVs, and cessation of HEV-DC interactions and lymphocyte immigration across the high-endothelial barrier.

Lymphocyte migration and autoimmunity induction rely on Formin-like 1-mediated actin network remodeling to push the lymphocyte nucleus through restrictive endothelial barriers.

A lipid mediator lysophosphatidic acid (LPA) derived from fibroblastic reticular cells regulates T-cell movement through the densely packed reticular network in lymph nodes in a manner dependent on the LPA receptor LPA₂-ROCK-myosin II.

A group of innate-like lymphocytes surveys the lymph node subcapsular sinus for bacterial and fungal invaders using a novel combination of chemoattractant and adhesion molecules.

A viable separation of function XRCC4 knock-in mutant mouse model recapitulates some aspects of XRCC4 deficiency in humans, notably the absence of immune deficiency.

The bZIP transcription factor C/EBPδ enhances expression both of selectin ligands and the chemokine receptor CCR6 on human mucosal-associated invariant T cells, supporting their efficient extravasation into inflamed tissue.

Multiple functions of human T lymphocytes are shown to be potentiated within a wide range of physiological cell and tissue rigidities.

Hematopoietic progenitor cells employ CD47 to engage thymic portal endothelial signal regulatory protein alpha for their transendothelial migration and thymic homing.

Altered lymphocyte dynamics after hematopoietic stem cell transplantation cannot solely be explained by low lymphocyte numbers.