Submucosal glands are critical for two key respiratory host defenses, bactericidal activity and mucociliary transport, in an animal model that has lungs like humans.
Two members of a widely studied family of chemoreceptors, the "orphan" chemoreceptor IR21a and its putative co-receptor IR25a, act together to mediate cool sensation in fruit fly larvae.
A dedicated structural element facilitates chaperone and antigenic peptide selector function of TAP-associated glycoprotein, a major quality assurance auditor in adaptive immunity.
The first inhibitor identified against an iso-enzyme that initiates O-glycosylation in the Golgi complex promises new therapeutic approaches for cancer and chronic kidney disease.
Endoplasmic reticulum proteostasis factors enhance the mutational tolerance of influenza hemagglutinin, a model secretory pathway protein and therapeutic target, particularly improving the fitness of temperature-sensitive variants.
An unbiased transcriptomic approach reveals that developing paddlefish electrosensory organs express genes essential for mechanosensory hair cell development and synaptic transmission, and identifies candidates for mediating electroreceptor development and function.
