Progesterone mediates nongenomic signaling in Xenopus oocyte meiosis by activating a PLA2 activity that requires two membrane receptors ABDH2 and mPRß.
NMR and clustering results show that N-terminal acetylation of α-syn enhances its binding to the neutral phospholipid lysophosphatidylcholine, thereby promoting its function of clustering synaptic vesicles.
Sphinganine-1-phosphate (SA1P) is linked to paclitaxel-induced peripheral neuropathy, offering a potential target for reducing this severe side effect of paclitaxel treatment.
Venkateshwari Varadharajan, Iyappan Ramachandiran ... J Mark Brown
MBOAT7 loss of function in hepatocytes contributes to ethanol-induced liver injury, offering crucial insights into the dysregulated lipid metabolism and impaired autophagy associated with advanced liver disease.
The iron-sulfur cluster containing Ferredoxin 1 (FDX1), critical in steroidogenesis and TCA cycle, is required for mammalian embryonic development and maintenance of lipid homeostasis at cellular and organismal levels.
Hiroaki Eshima, Justin L Shahtout ... Katsuhiko Funai
Genetic or pharmacological suppression of lipid peroxidation pathway protects skeletal muscle from disuse-induced atrophy and weakness in young and old mice.
