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    1. Neuroscience

    Auditory perception and neural representation of temporal fine structure are impaired by age but not by cochlear synaptopathy

    Friederike Steenken, Rainer Beutelmann ... Georg M Klump
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Chromosomes and Gene Expression

    Sir2 and Fun30 regulate ribosomal DNA replication timing via MCM helicase positioning and nucleosome occupancy

    Carmina Lichauco, Eric J Foss ... Antonio Bedalov
    Precocious ribosomal DNA replication in sir2 mutants requires Fun30.
    1. Structural Biology and Molecular Biophysics

    Wide Transition-State Ensemble as Key Component for Enzyme Catalysis

    Gabriel Ernesto Jara, Francesco Pontiggia ... Dorothee Kern
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Solid
    • Incomplete
    1. Computational and Systems Biology
    2. Structural Biology and Molecular Biophysics

    Discovery of a heparan sulfate binding domain in monkeypox virus H3 as an anti-poxviral drug target combining AI and MD simulations

    Bin Zheng, Meimei Duan ... Peng Zheng
    The identification of a conserved α-helical domain in monkeypox virus H3 protein as critical for heparan sulfate binding unveils a novel therapeutic target, validated through AI and molecular dynamics simulations, offering potential for broad-spectrum antiviral development.
    1. Immunology and Inflammation

    Early and delayed STAT1-dependent responses drive local trained immunity of macrophages in the spleen

    Aryeh Solomon, Noa Bossel Ben-Moshe ... Roi Avraham
    In vivo perturbations and single-cell RNA-seq reveal cell-type-specific STAT1-IFNg signaling in regulation of trained immunity in tissue-resident immune cells.
    1. Neuroscience

    Behavioural pharmacology predicts disrupted signalling pathways and candidate therapeutics from zebrafish mutants of Alzheimer’s disease risk genes

    François Kroll, Joshua Donnelly ... Jason Rihel
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Genetics and Genomics
    2. Evolutionary Biology

    The Primate Major Histocompatibility Complex: An Illustrative Example of Gene Family Evolution

    Alyssa Lyn Fortier, Jonathan K Pritchard
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Computational and Systems Biology

    AI-driven automated discovery tools reveal diverse behavioral competencies of biological networks

    Mayalen Etcheverry, Clément Moulin-Frier ... Michael Levin
    A novel methodology, using diversity search AI algorithms, for exploring the space of possible behaviors of gene regulatory networks, from the perspective of generic problem-solving agents navigating their environment.
    1. Neuroscience

    Nitric oxide modulates contrast suppression in a subset of mouse retinal ganglion cells

    Dominic Gonschorek, Matías A Goldin ... Thomas Euler
    Nitric oxide is a type-selective neuromodulator affecting the temporal, but not the spatial response kinetics of a specific subset of mouse retinal ganglion cells.
    1. Genetics and Genomics
    2. Evolutionary Biology

    Ancient Trans-Species Polymorphism at the Major Histocompatibility Complex in Primates

    Alyssa Lyn Fortier, Jonathan K Pritchard
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
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