179 results found
    1. Stem Cells and Regenerative Medicine

    Activating the regenerative potential of Müller glia cells in a regeneration-deficient retina

    Katharina Lust, Joachim Wittbrodt
    Müller glia cells in the medaka (Oryzias latipes) retina act as lineage restricted progenitors which only regenerate photoreceptors but can be activated to perform as potent stem cells using Sox2.
    1. Neuroscience

    Neuron-glia signaling in developing retina mediated by neurotransmitter spillover

    Juliana M Rosa et al.
    Retinal waves are correlated with calcium transients in Müller cells, demonstrating that spontaneous activity encompasses both neuronal and glial networks during a crucial period of retinal development.
    1. Neuroscience

    Vocal development in a Waddington landscape

    Yayoi Teramoto et al.
    An integrated landscape framework shows how the coordinated changes in vocal apparatus, muscles, nervous system, and social interaction together influence the trajectory of vocal development.
    1. Neuroscience

    Motor control of Drosophila feeding behavior

    Olivia Schwarz et al.
    The neuroanatomical and functional analysis of genetically-identified motoneurons controlling all major steps of Drosophila proboscis extension provides new insights into the architecture of a motor circuitry controlling a reaching-like behavior.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    The LIM protein complex establishes a retinal circuitry of visual adaptation by regulating Pax6 α-enhancer activity

    Yeha Kim et al.
    Regulation of Pax6 expression through the α-enhancer fine-tunes amacrine cell subtype number, and consequently, the visual output of the retina.
    1. Chromosomes and Gene Expression

    A gene-specific T2A-GAL4 library for Drosophila

    Pei-Tseng Lee et al.
    A library of a thousand gene-specific intronic GAL4 insertions was generated, which caused a severe loss of function, permitted the assessing of gene expression, allowed the rescue of mutated gene with UAS-cDNA constructs, and provided a tool for the reversion of mutant phenotypes in specific cells or tissues.
    1. Neuroscience

    Formation of retinal direction-selective circuitry initiated by starburst amacrine cell homotypic contact

    Thomas A Ray et al.
    Selective synapse formation in a retinal motion-sensitive circuit is orchestrated by starburst amacrine cells, which use homotypic interactions to initiate formation of a dendritic scaffold that recruits projections from circuit partners.
    1. Neuroscience

    Orphan receptor GPR158 controls stress-induced depression

    Laurie P Sutton et al.
    The orphan receptor GPR158 is highly regulated by stress exposure and acts on key neuronal signaling pathways in the prefrontal cortex to control depressive-like behaviors.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Biochemical adaptations of the retina and retinal pigment epithelium support a metabolic ecosystem in the vertebrate eye

    Mark A Kanow et al.
    Metabolic relationships between cells in the retina and retinal pigment epithelium are fundamental to retinal function, retinal disease and age-related vision loss and they may provide strategies for metabolism-based therapies.
    1. Neuroscience

    Tracking individual action potentials throughout mammalian axonal arbors

    Milos Radivojevic et al.
    A method was developed to non-invasively and simultaneously track individual action-potentials propagating across multiple branches of identified neurons in neocortical cultures.

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