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    1. Neuroscience

    Hunger neurons drive feeding through a sustained, positive reinforcement signal

    Yiming Chen, Yen-Chu Lin ... Zachary A Knight
    Hunger neurons promote feeding by triggering a long-lasting potentiation of the rewarding properties of food.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Nuclear genetic regulation of the human mitochondrial transcriptome

    Aminah T Ali, Lena Boehme ... Alan Hodgkinson
    Common nuclear genetic variants are associated with fundamental biological processes occurring in human mitochondria and potentially point to novel roles for nuclear genes in transcriptional regulation of the mitochondrial genome.
    1. Neuroscience

    Offline replay supports planning in human reinforcement learning

    Ida Momennejad, A Ross Otto ... Kenneth A Norman
    fMRI evidence for off-task replay predicts subsequent replanning behavior in humans, suggesting that learning from simulated experience during replay helps update past policies in reinforcement learning.
    1. Chromosomes and Gene Expression

    Noncoding RNA-nucleated heterochromatin spreading is intrinsically labile and requires accessory elements for epigenetic stability

    R A Greenstein, Stephen K Jones ... Bassem Al-Sady
    Heterochromatin spreading in fission yeast predominantly produces intergenerationally unstable outcomes, requiring an accessory element that represses histone turnover.
    1. Microbiology and Infectious Disease

    An improved bacterial single-cell RNA-seq reveals biofilm heterogeneity

    Xiaodan Yan, Hebin Liao ... Yingying Pu
    RiboD-PETRI, a cost-effective, equipment-free plate-based scRNA-seq technique that integrates a unique bacterial rRNA depletion protocol, significantly enhancing mRNA detection rate and revealing within-population heterogeneity, offering valuable insights for research applications.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Functional reconstitution of a bacterial CO2 concentrating mechanism in Escherichia coli

    Avi I Flamholz, Eli Dugan ... David F Savage
    A bacterial CO2 concentrating mechanism enables Escherichia coli to fix CO2 from ambient air into biomass.
    1. Neuroscience

    The Digital Brain Bank, an open access platform for post-mortem imaging datasets

    Benjamin C Tendler, Taylor Hanayik ... Karla L Miller
    The Digital Brain Bank (open.win.ox.ac.uk/DigitalBrainBank) provides curated post-mortem imaging datasets for neuroanatomy, neuropathology, and comparative neuroanatomy investigations, with the first release containing 21 distinctive whole-brain diffusion MRI datasets, alongside microscopy and complementary MRI modalities.
    1. Epidemiology and Global Health
    2. Medicine

    Effective control of SARS-CoV-2 transmission between healthcare workers during a period of diminished community prevalence of COVID-19

    Nick K Jones, Lucy Rivett ... Michael P Weekes
    Diminished incidence of COVID-19 amongst healthcare workers in a comprehensive screening programme demonstrates how effective infection control measures and staff testing can prevent hospitals becoming independent 'hubs' of SARS-CoV-2 transmission.
    1. Computational and Systems Biology

    Metabolic network percolation quantifies biosynthetic capabilities across the human oral microbiome

    David B Bernstein, Floyd E Dewhirst, Daniel Segrè
    A novel metabolic network analysis method enables large-scale computational predictions of biosynthetic capabilities across the human oral microbiome, revealing a unique cluster of fastidious microorganisms and potential metabolic interdependencies.
    1. Neuroscience

    Sensory cortex is optimized for prediction of future input

    Yosef Singer, Yayoi Teramoto ... Nicol S Harper
    Prediction of future input explains diverse neural tuning properties in sensory cortex.