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    1. Neuroscience

    Analysis of the immune response to sciatic nerve injury identifies efferocytosis as a key mechanism of nerve debridement

    Ashley L Kalinski, Choya Yoon ... Roman J Giger
    In the injured sciatic nerve, blood-derived monocytes and macrophages eat dying leukocytes, thereby contributing to nerve debridement and inflammation resolution, and this correlates with neuronal regeneration.
    1. Neuroscience

    Age-related differences in prefrontal glutamate are associated with increased working memory decay that gives the appearance of learning deficits

    Milena Rmus, Mingjian He ... Matthew R Nassar
    Apparent age-related differences in learning are best accounted for by rapid decay of information in working memory, which is associated with levels of prefrontal glutamate.
    1. Neuroscience

    Assessment of neurovascular coupling and cortical spreading depression in mixed mouse models of atherosclerosis and Alzheimer’s disease

    Osman Shabir, Ben Pendry ... Jason Berwick
    Mice modelling atherosclerosis show neurovascular breakdown in the cortex compared to healthy controls, and inducing atherosclerosis in mice modelling Alzheimer's disease increases the number of amyloid plaques in the hippocampus.
    1. Cancer Biology
    2. Cell Biology

    Cyclin F drives proliferation through SCF-dependent degradation of the retinoblastoma-like tumor suppressor p130/RBL2

    Taylor P Enrico, Wayne Stallaert ... Michael J Emanuele
    The SCF-family of ubiquitin ligases regulates the key cancer proliferation node by controlling the degradation of RB-like tumor suppressor RBL2/p130.
    1. Stem Cells and Regenerative Medicine

    RNA-binding proteins direct myogenic cell fate decisions

    Joshua R Wheeler, Oscar N Whitney ... Bradley B Olwin
    Temporally regulated RNA-binding proteins orchestrate RNA splicing to drive myogenesis.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Profiling the bloodstream form and procyclic form Trypanosoma brucei cell cycle using single-cell transcriptomics

    Emma M Briggs, Catarina A Marques ... Keith R Matthews
    Single-cell transcriptomics of cryopreserved parasites reveals extensive cyclic regulation of mRNA abundance by Trypanosoma brucei during the cell cycle.
    1. Neuroscience

    Aquaporin-4-dependent glymphatic solute transport in the rodent brain

    Humberto Mestre, Lauren M Hablitz ... Maiken Nedergaard
    An international collaboration between five independent research groups replicates findings confirming the importance of aquaporin-4 in glymphatic solute transport using five different mouse knockout lines.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Meningeal lymphatic drainage promotes T cell responses against Toxoplasma gondii but is dispensable for parasite control in the brain

    Michael A Kovacs, Maureen N Cowan ... Tajie H Harris
    In the setting of CNS infection, meningeal lymphatic drainage promotes dendritic cell and T cell responses in the deep cervical lymph nodes but is not necessary for maintaining control of parasite in the brain.
    1. Neuroscience

    Therapeutic effects of anodal transcranial direct current stimulation in a rat model of ADHD

    Da Hee Jung, Sung Min Ahn ... Byung Tae Choi
    High-definition anodal transcranial stimulation alleviated cognitive deficits, affected dopaminergic neurotransmission factors, increased expression of several neurotrophic factors involving brain-derived neurotrophic factor (BDNF), and activated hippocampal neurogenesis.
    1. Cancer Biology

    FABP4-mediated lipid accumulation and lipolysis in tumor-associated macrophages promote breast cancer metastasis

    Matthew Yorek, Xingshan Jiang ... Bing Li
    FABP4 plays a central role in driving the formation lipid-laden macrophages induced by unsaturated fats and enhances macrophage-tumor interactions, thereby promoting breast cancer migration and metastasis.