Mathematical models with experimental validation show that chloride transporters in the cell membrane, and not negatively charged impermeant molecules, generate the driving force used by GABA receptors to silence neurons.

Increased production of ether lipids is required to extend lifespan in response to metformin, phenformin, and multiple, distinct, longevity-promoting manipulations, illuminating the possibility that raising ether lipid levels represents a new therapeutic strategy to support healthy aging.

The phytocannabinoid cannabidiol, an antiepileptic agent whose molecular targets are unclear, was found to potently enhance current carried by cloned human Kv7.2/7.3 channels and native M-current in mouse and rat neurons.

An inducedpluripotent stem cell (iPSC)-based model of KCNQ2-associated developmental epileptic encephalopathy suggests that disease is driven by dyshomeostaic neuronal mechanisms that are downstream of loss of M-current.

A genome scale model of Brugia malayi metabolism illustrates a dynamic reliance on energy production pathways across its life cycle and identifies new drugs with experimentally supported anti-parasitic properties.

Formation of dorsal axonal tracts in the spinal cord depends on multiple guidance mechanisms that control growth direction of bifurcating axons in the dorsal root entry zone.

Leveraging the US Health and Retirement Study and C. elegans genetics reveals ALDH4A1/alh-6 as an evolutionarily conserved biomarker for normal muscle function over the lifespan.

Characterisation of within-host diversity of SARS-CoV-2 provides insights into the mutational and selective mechanisms driving its evolution and has important implications for using within-host variation to inform transmission inference efforts.

During Drosophila axis elongation, the orientational pattern of the cytoskeleton is in good approximation stationary, while the genes thought to instruct these patterns are transported with the tissue flow.

Analysis of genomic DNA composition of surface plankton communities reveals a stable, ocean basin-scale plankton biogeography that emerges from the intertwined effects of environmental variations and currents.