149 results found
    1. Cancer Biology
    2. Immunology and Inflammation

    Human primed ILCPs support endothelial activation through NF-κB signaling

    Giulia Vanoni et al.
    Circulating human primed innate lymphoid cell precursors have the potential to functionally induce adhesion molecules' expression in endothelial cells and possibly support the immune cells' infiltration into the tumor site.
    1. Epidemiology and Global Health

    Antimicrobial resistance and COVID-19: Intersections and implications

    Gwenan M Knight et al.
    COVID-19 will have an ongoing impact on antimicrobial resistance acquisition, transmission, and burden, requiring the close attention of researchers globally to generate a complete evidence base for the shifted dynamics.
    1. Evolutionary Biology

    Whole genome phylogenies reflect the distributions of recombination rates for many bacterial species

    Thomas Sakoparnig et al.
    For many bacterial species, recombination dominates genome evolution and phylogenetic patterns that have so far been assumed to reflect clonal relationships, in fact reflect variation in recombination rates across lineages.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    In-host population dynamics of Mycobacterium tuberculosis complex during active disease

    Roger Vargas et al.
    Bulk whole genome sequencing data can be used to study the genetic variation present in pathogenic bacterial populations over the time-course of a single infection within a host.
    1. Genetics and Genomics
    2. Plant Biology

    The Arabidopsis active demethylase ROS1 cis-regulates defence genes by erasing DNA methylation at promoter-regulatory regions

    Thierry Halter et al.
    Active DNA demethylation at some defence gene promoters is causal for DNA binding of WRKY transcription factors as well as for transcriptional activation of these genes during plant immune response.
    1. Microbiology and Infectious Disease

    A live attenuated-vaccine model confers cross-protective immunity against different species of the Leptospira genus

    Elsio A Wunder et al.
    A single dose of a characterized motility-deficient mutant was sufficient to induce robust anti-protein antibodies' response and cross-protective immunity against death and colonization in two different animal models of leptospirosis.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    A Bayesian analysis of the association between Leukotriene A4 Hydrolase genotype and survival in tuberculous meningitis

    Laura Whitworth et al.
    In this ideal example of pharmacogenomics, individuals with a common variant in a gene encoding for an inflammatory lipid mediator benefit selectively from standard-of-care anti-inflammatory treatment used for tuberculous meningitis.
    1. Neuroscience

    Analysis of the immune response to sciatic nerve injury identifies efferocytosis as a key mechanism of nerve debridement

    Ashley L Kalinski et al.
    In the injured sciatic nerve, blood-derived monocytes and macrophages eat dying leukocytes, thereby contributing to nerve debridement and inflammation resolution, and this correlates with neuronal regeneration.
    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    A lung-on-chip model of early Mycobacterium tuberculosis infection reveals an essential role for alveolar epithelial cells in controlling bacterial growth

    Vivek V Thacker et al.
    Time-lapse imaging and the modular recreation of host physiology reveal that alveolar epithelial cells, potential permissive infection sites for Mycobacterium tuberculosis, can restrict early bacterial growth via surfactant secretion.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Spreading of a mycobacterial cell-surface lipid into host epithelial membranes promotes infectivity

    CJ Cambier et al.
    Applying bioorthogonal chemistry to the zebrafish/Mycobacterium marinum model of tuberculosis reveals that the virulence lipid PDIM must spread into epithelial cells in order for mycobacteria to establish infection.

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