137 results found
    1. Biochemistry and Chemical Biology

    Adipocyte ALK7 links nutrient overload to catecholamine resistance in obesity

    Tingqing Guo, Patricia Marmol ... Carlos F Ibanez
    The ALK7 receptor functions cell-autonomously and homeostatically in adult adipocytes to regulate catecholamine sensitivity in response to the diet.
    1. Developmental Biology
    2. Immunology and Inflammation

    Identification of polarized macrophage subsets in zebrafish

    Mai Nguyen-Chi, Béryl Laplace-Builhe ... Farida Djouad
    The discovery of evolutionarily conserved macrophage subsets in zebrafish paves the way for a comprehensive study of macrophage behaviour and function.
    1. Computational and Systems Biology
    2. Neuroscience

    A cholinergic feedback circuit to regulate striatal population uncertainty and optimize reinforcement learning

    Nicholas T Franklin, Michael J Frank
    Computational modeling suggests that feedback between striatal cholinergic neurons and spiny neurons dynamically adjusts learning rates to optimize behavior in a variable world.
    1. Cell Biology
    2. Immunology and Inflammation

    Akt-mTORC1 signaling regulates Acly to integrate metabolic input to control of macrophage activation

    Anthony J Covarrubias, Halil Ibrahim Aksoylar ... Tiffany Horng
    Interleukin 4 signaling co-opts the Akt-mTORC1-Acly pathway to couple metabolic input to the control of energetically demanding processes during macrophage M2 activation.
    1. Cell Biology
    2. Neuroscience

    Excitatory transmission onto AgRP neurons is regulated by cJun NH2-terminal kinase 3 in response to metabolic stress

    Santiago Vernia, Caroline Morel ... Roger J Davis
    Metabolic stress-induced activation of the JNK3 protein regulates excitatory transmission onto AgRP neurons to regulate food consumption.
    1. Neuroscience

    Target-specific membrane potential dynamics of neocortical projection neurons during goal-directed behavior

    Takayuki Yamashita, Carl CH Petersen
    A learning-induced, motor-related, projection-specific signal from S1 to S2 accompanies reward-based-learning of a goal-directed sensorimotor transformation of whisker sensation into licking motor output.
    1. Immunology and Inflammation

    Pivotal role for skin transendothelial radio-resistant anti-inflammatory macrophages in tissue repair

    Olga Barreiro, Danay Cibrian ... Francisco Sánchez Madrid
    A new type of skin perivascular macrophages with extramedullary origin, access to blood and exclusive anti-inflammatory reparative properties has been characterized.
    1. Chromosomes and Gene Expression

    Tissue damage drives co-localization of NF-κB, Smad3, and Nrf2 to direct Rev-erb sensitive wound repair in mouse macrophages

    Dawn Z Eichenfield, Ty Dale Troutman ... Christopher K Glass
    Combinatorial signaling leads to transcription factor co-localization at Rev-erb sensitive enhancers, enabling a diversified cellular response to complex stimuli.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Diverse fates of uracilated HIV-1 DNA during infection of myeloid lineage cells

    Erik C Hansen, Monica Ransom ... James T Stivers
    Uracil/adenine base pairs in HIV-1 DNA are attacked by the uracil base excision repair machinery in macrophages, which leads to HIV restriction and viral genome diversification by transcription-associated mutagenesis.
    1. Neuroscience

    Feedforward motor information enhances somatosensory responses and sharpens angular tuning of rat S1 barrel cortex neurons

    Mohamed Khateb, Jackie Schiller, Yitzhak Schiller
    Primary motor cortex afferents supra-linearly amplify the responses and sharpen angular tuning of neurons in the S1 barrel cortex.

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