Heparan sulfate synthesis by mature oligodendrocytes creates a protective and permissive environment controling microglia and oligodendrocyte progenitors reactivation during remyelination.
Veronika Miskolci, Kelsey E Tweed ... Anna Huttenlocher
Lifetime imaging of endogenous metabolic coenzymes is sensitive to dynamic changes in macrophage activation in a live animal, providing a label-free imaging approach to study immunometabolism in vivo with single-cell, spatial, and temporal resolution.
A learning-induced, motor-related, projection-specific signal from S1 to S2 accompanies reward-based-learning of a goal-directed sensorimotor transformation of whisker sensation into licking motor output.
Dawn Z Eichenfield, Ty Dale Troutman ... Christopher K Glass
Combinatorial signaling leads to transcription factor co-localization at Rev-erb sensitive enhancers, enabling a diversified cellular response to complex stimuli.
The new drug 3,6’-dithiopomalidomide mitigates key markers of neuronal death and neuroinflammation and improves acute behavioral outcome measures in traumatic brain injury, a common, debilitating disorder that lacks effective treatment.
Teresa WM Fan, Richard M Higashi ... Andrew N Lane
Pembrolizumab activates innate immune metabolism and function in primary human non-small cell lung cancer, whereas Pembrolizumab and beta-glucan synergize in enhancing immune metabolism and tumoridical action in brain-metastasized lung cancer.
Laura Alonso-Herranz, Álvaro Sahún-Español ... Mercedes Ricote
Macrophage production of MT1-MMP upon MI contributes to adverse cardiac remodeling and worsened function by promoting EndMT via TGFB, suggesting MT1-MMP inhibition as a therapeutic option for patients with MI.
A multiomics, systems biology approach was used to define the metabolic and signaling programs that drive the fate and function of pancreatic tumor-associated macrophages.
