142 results found
    1. Chromosomes and Gene Expression
    2. Cancer Biology

    Premature polyadenylation of MAGI3 produces a dominantly-acting oncogene in human breast cancer

    Thomas K Ni, Charlotte Kuperwasser
    The study of a recurrent breast cancer MAGI3 truncation reveals the role of MAGI3 in regulating the Hippo effector YAP and highlights premature mRNA cleavage and polyadenylation as a mechanism underlying cancer development.
    1. Structural Biology and Molecular Biophysics

    Decoding WW domain tandem-mediated target recognitions in tissue growth and cell polarity

    Zhijie Lin et al.
    A systematic and quantitative investigation showing how highly specific WW domain-mediated protein-protein interaction network is organized in cell growth and polarity.
    1. Cell Biology

    Novel origin of lamin-derived cytoplasmic intermediate filaments in tardigrades

    Lars Hering et al.
    A newly discovered cytoplasmic intermediate filament in water bears may help these animals to resist extreme environmental conditions.
    1. Neuroscience

    Magnesium efflux from Drosophila Kenyon cells is critical for normal and diet-enhanced long-term memory

    Yanying Wu et al.
    Regulated neuronal magnesium efflux is a critical element of normal and magnesium-enhanced memory.
    1. Computational and Systems Biology
    2. Plant Biology

    An ABA-GA bistable switch can account for natural variation in the variability of Arabidopsis seed germination time

    Katie Abley et al.
    Arabidopsis shows extensive genetic diversity in germination time distributions, which can be explained by the underlying ABA/GA network functioning as a noisy bistable switch.
    1. Physics of Living Systems

    Decoding the physical principles of two-component biomolecular phase separation

    Yaojun Zhang et al.
    Phase separation of two-component multivalent systems is suppressed at rational polymer stoichiometries, suggesting possible cellular strategies for regulating the formation and function of biomolecular condensates.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Structural heterogeneity of cellular K5/K14 filaments as revealed by cryo-electron microscopy

    Miriam S Weber et al.
    Keratins assemble into tubular filaments with a central density and exhibit structural heterogeneity, which is reflected in alterations of the helical arrangement.
    1. Genetics and Genomics

    Minimal-assumption inference from population-genomic data

    Daniel B Weissman, Oskar Hallatschek
    The coalescent history of a population can be learned just from the present genomic diversity, without having detailed prior knowledge of the pattern of recombination or the forces driving coalescence.
    1. Developmental Biology

    Development: Computing away the magic?

    Michael Levine
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