2,934 results found
    1. Developmental Biology
    2. Neuroscience

    Layer specific and general requirements for ERK/MAPK signaling in the developing neocortex

    Lei Xing et al.
    Aberrant ERK/MAPK signaling in cortical pyramidal neurons leads to selective disruption of layer 5 circuit development and generalized changes in neuronal excitability.
    1. Cell Biology
    2. Neuroscience

    MAPK signaling promotes axonal degeneration by speeding the turnover of the axonal maintenance factor NMNAT2

    Lauren J Walker et al.
    Genetic and biochemical analysis reveals that MAPK signaling promotes axon degeneration by modulating the turnover of axon-protective proteins.
    1. Developmental Biology
    2. Neuroscience

    Glial and neuronal Semaphorin signaling instruct the development of a functional myotopic map for Drosophila walking

    Durafshan Sakeena Syed et al.
    Signaling from glia and nerves regulate the development of axonal and dendritic motor neuron architecture, needed for walking in the fruit fly species Drosophila.
    1. Cancer Biology

    Epithelial-Myeloid cell crosstalk regulates acinar cell plasticity and pancreatic remodeling in mice

    Yaqing Zhang et al.
    In the pancreas, reciprocal interactions between epithelial cells and myeloid cells determine the balance between tissue repair and carcinogenesis by regulating acinar cell plasticity through differential activation of EGFR/MAPK signaling.
    1. Cell Biology
    2. Computational and Systems Biology

    Rewiring MAP kinases in Saccharomyces cerevisiae to regulate novel targets through ubiquitination

    Benjamin Groves et al.
    Two sets of modular components are sufficient to rewire MAPKs to regulate proteins through ubiquitination – a complementary pair of protein interaction domains and a phosphodegron.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Stress-activated MAPK signaling controls fission yeast actomyosin ring integrity by modulating formin For3 levels

    Elisa Gómez-Gil et al.
    Microscopic and biochemical analysis show that the stress-activated MAP kinase pathway targets the formin For3 to modulate actomyosin ring integrity in response to environmental cues.
    1. Biochemistry and Chemical Biology

    AMPK signaling to acetyl-CoA carboxylase is required for fasting- and cold-induced appetite but not thermogenesis

    Sandra Galic et al.
    A single mutation in acetyl-CoA carboxylase blocking AMPK regulation inhibits food intake in mice in response to cold exposure or fasting causing them to lose weight.
    1. Cell Biology
    2. Immunology and Inflammation

    Attenuation of AMPK signaling by ROQUIN promotes T follicular helper cell formation

    Roybel R Ramiscal et al.
    The ubiquitin ligase ROQUIN cross-talks with cellular metabolic signals to generate protective T cell-dependent antibody responses.
    1. Developmental Biology

    The Warburg Effect and lactate signaling augment Fgf-MAPK to promote sensory-neural development in the otic vesicle

    Husniye Kantarci et al.
    Glycolysis is locally enhanced and redirected in zebrafish to generate lactate, which functions as a signaling molecule to fully activate Fgf target genes required for proper sensory and neural development.
    1. Chromosomes and Gene Expression

    Yeast Nuak1 phosphorylates histone H3 threonine 11 in low glucose stress by the cooperation of AMPK and CK2 signaling

    Seunghee Oh et al.
    Yeast Nuak1 is an AMPK and CK2 dependent H3 T11 kinase.

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