303 results found
    1. Microbiology and Infectious Disease

    Strong inter-population cooperation leads to partner intermixing in microbial communities

    Babak Momeni, Kristen A Brileya ... Wenying Shou
    Simulations and experiments on systems containing two different populations of microorganisms show that interactions that benefit at least one of the populations can lead to communities with stable compositions, and that strong cooperation between two populations can lead to communities in which both populations are mixed together.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Sterol homeostasis requires regulated degradation of squalene monooxygenase by the ubiquitin ligase Doa10/Teb4

    Ombretta Foresti, Annamaria Ruggiano ... Pedro Carvalho
    Parallel branches of the ERAD pathway regulate sterol synthesis at multiple steps via feedback inhibition.
    1. Ecology

    Spatial self-organization favors heterotypic cooperation over cheating

    Babak Momeni, Adam James Waite, Wenying Shou
    Two cooperative populations of yeast cells that cannot distinguish between cooperative partners and cheating intruders can still self-organize into clusters that exclude cheaters.
    1. Cell Biology
    2. Evolutionary Biology

    tRNA genes rapidly change in evolution to meet novel translational demands

    Avihu H Yona, Zohar Bloom-Ackermann ... Yitzhak Pilpel
    Experimental evolution and systematic sequence analysis of transfer RNA genes reveal that anticodon mutations provide adaptive plasticity to the translation machinery.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Fluorescent sensors for activity and regulation of the nitrate transceptor CHL1/NRT1.1 and oligopeptide transporters

    Cheng-Hsun Ho, Wolf B Frommer
    Peptide and nitrate transporters have been converted into fluorescent reporters of transport activity and have been used to measure various transport properties including the dual affinity of the nitrate transceptor
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Bacterial autolysins trim cell surface peptidoglycan to prevent detection by the Drosophila innate immune system

    Magda Luciana Atilano, Pedro Matos Pereira ... Sérgio Raposo Filipe
    To avoid recognition by the immune system, bacteria use autolysins to trim fragments of peptidoglycans that are exposed on the bacterial cell wall.
    1. Cell Biology
    2. Plant Biology

    Abscisic acid dynamics in roots detected with genetically encoded FRET sensors

    Alexander M Jones, Jonas ÅH Danielson ... Wolf B Frommer
    Fluorescent sensors for the hormone abscisic acid have been developed using a high-throughput platform, and used to monitor hormone dynamics in plant roots and leaves.
    1. Chromosomes and Gene Expression

    The budding yeast Centromere DNA Element II wraps a stable Cse4 hemisome in either orientation in vivo

    Steven Henikoff, Srinivas Ramachandran ... Jorja G Henikoff
    A stable tetrameric nucleosome occupies the central segment of each ∼120-bp budding yeast centromere in two rotational phases of both reflectional orientations in vivo.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    Requirement for highly efficient pre-mRNA splicing during Drosophila early embryonic development

    Leonardo Gastón Guilgur, Pedro Prudêncio ... Rui Gonçalo Martinho
    The need for efficient pre-RNA splicing during early embryonic development of Drosophila indicates that the constraints imposed by the cell cycle are a force capable of driving changes in Eukaryotic gene architecture.
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    Genome-wide dynamics of Pol II elongation and its interplay with promoter proximal pausing, chromatin, and exons

    Iris Jonkers, Hojoong Kwak, John T Lis
    The elongation rate of RNA Polymerase II varies greatly between and along genes, as this enzyme accelerates from stable pausing to rapid elongation within genes, and is influenced by CG-content, exons and chromatin.

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