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Substantial heritable genetic variation in adaptability and the pleiotropic consequences of adaptation exists in budding yeast, and can be explained by a combination of fitness and specific segregating alleles.

The discovery of new skeletal remains of Homo naledi in the Lesedi Chamber, South Africa, adds more evidence to our understanding of the morphology and behavior of this recently discovered species.

A new approach measures the respective participations of elementary cell behaviors – such as cell division, intercalation, shape change and death – in the shaping of animal tissues.

A new in vitro approach allows measurement of the efficiency of the early steps of translation initiation on every messenger RNA in yeast simultaneously.

Uso1 critically regulating traffic in the ER/Golgi interface is a coiled-coil protein traditionally regarded as a tether, but a forward genetic screen revealed that its essential role appears to involve its ability to interact with SNAREs.

Exploring natural Hsp104 variation reveals unexpected tuning of a passive activity that inhibits aggregation of specific substrates to selectively counter TDP-43 or alpha-synuclein proteotoxicity connected to neurodegenerative disease.

Repulsive guidance cues enhance a dual-functioning axonal trafficking facilitator, allowing navigating axons to ensure proper pathfinding by coordinating positive extension and negative steering during nervous system development.

A CRISPR/Cas9 base editor screen allows probing interactions between large numbers of known mutations and the abundance of specific proteins to study the protein regulatory network in yeast.

Kipferl, a ZAD zinc finger protein from Drosophila, determines the chromatin binding specificity of the heterochromatin protein variant Rhino, defining piRNA clusters and preventing Rhino sequestration by selfish Satellite repeats.